PDF(Pubmed)
Abstract：
Exercise plays an important role in regulating energy homeostasis, which affects the diversity of the intestinal microbial community in humans and animals. To the best of the authors\' knowledge, few studies have reported the associations between horse gut microbiota along with their predicted metabolic activities and the athletic ability of Jeju horses and Thoroughbreds living in Korea. This study was conducted to investigate the association between the gut microbiota and athletic performance in horses. This study sequenced the V3 and V4 hypervariable regions of the partial 16S rRNA genes obtained from racehorse fecal samples and compared the fecal microbiota between high- and low-performance Jeju horses and Thoroughbreds. Forty-nine fecal samples were divided into four groups: high-performance Jeju horses (HJ, n = 13), low-performance Jeju horses (LJ, n = 17), high-performance Thoroughbreds (HT, n = 9), and low-performance Thoroughbreds (LT, n = 10). The high-performance horse groups had a higher diversity of the bacterial community than the low-performance horse groups. Two common functional metabolic activities of the hindgut microbiota (i.e., tryptophan and succinate syntheses) were observed between the low-performance horse groups, indicating dysbiosis of gut microbiota and fatigue from exercise. On the other hand, high-performance horse groups showed enriched production of polyamines, butyrate, and vitamin K. The racing performance may be associated with the composition of the intestinal microbiota of Jeju horses and Thoroughbreds in Korea.
摘要：
运动在调节能量稳态方面起着重要作用，影响人类和动物肠道微生物群落的多样性。据作者所知，很少有研究报道了生活在韩国的济州马和纯种马的肠道微生物群及其预测的代谢活动与运动能力之间的关联。进行这项研究是为了调查马的肠道微生物群与运动表现之间的关联。这项研究对从赛马粪便样品中获得的部分16SrRNA基因的V3和V4高变区进行了测序，并比较了高性能和低性能济州马和纯种马之间的粪便微生物群。49个粪便样本分为四组：高性能济州马（HJ，n=13),低性能济州马(LJ，n=17),高性能纯种(HT，n=9),和低性能的纯种(LT，n=10)。高性能马组的细菌群落多样性高于低性能马组。后肠微生物群的两种常见功能代谢活动(即，色氨酸和琥珀酸合成）在低性能马组之间观察到，表明肠道微生物群失调和运动疲劳。另一方面,高性能马群显示出丰富的多胺产量，丁酸盐,和维生素K。赛车性能可能与韩国济州马和纯血马的肠道微生物群的组成有关。
