PDF(Pubmed)
Abstract：
Trillions of intestinal bacteria in the human body undergo dynamic transformations in response to physiological and pathological changes. Alterations in their composition and metabolites collectively contribute to the progression of Alzheimer\'s disease. The role of gut microbiota in Alzheimer\'s disease is diverse and complex, evidence suggests lipid metabolism may be one of the potential pathways. However, the mechanisms that gut microbiota mediate lipid metabolism in Alzheimer\'s disease pathology remain unclear, necessitating further investigation for clarification. This review highlights the current understanding of how gut microbiota disrupts lipid metabolism and discusses the implications of these discoveries in guiding strategies for the prevention or treatment of Alzheimer\'s disease based on existing data.
摘要：
人体中数万亿的肠道细菌响应生理和病理变化而发生动态转化。它们的组成和代谢物的改变共同促进了阿尔茨海默病的进展。肠道菌群在阿尔茨海默病中的作用是多样而复杂的,有证据表明，脂质代谢可能是潜在的途径之一。然而,肠道菌群在阿尔茨海默病病理中介导脂质代谢的机制尚不清楚，需要进一步调查以澄清。这篇综述强调了目前对肠道微生物群如何破坏脂质代谢的理解，并根据现有数据讨论了这些发现在指导阿尔茨海默病预防或治疗策略中的意义。
