METHODS: We systematically searched four databases (PubMed, Embase, Web of Science, and Cochrane Library) for randomized controlled trials (RCTs) investigating PDT + CMD for p-iM from their inception to March 13, 2023. Meta-analysis was performed using RevMan 5.4 software.
RESULTS: Seven RCTs met the inclusion criteria. The meta-analysis revealed that PDT + CMD treatment was more effective than CMD alone in reducing probing depth (PD) (Mean Difference [MD]: -1.09, 95% Confidence Interval [CI]: -1.99 to -0.2, P = 0.02) and plaque index (PI) (MD: -2.06, 95% CI: -2.81 to -1.31, P < 0.00001). However, there was no statistically significant difference in the improvement of bleeding on probing (BOP) between the PDT + CMD groups and CMD groups (MD: -0.97, 95% CI: -2.81 to 0.88, P = 0.31).
CONCLUSIONS: Based on the current available evidence, this meta-analysis indicates that the addition of PDT to CMD significantly improves PD and PI compared to CMD alone in the treatment of p-iM. However, there is no significant difference in improving BOP.
方法:我们系统地搜索了四个数据库(PubMed,Embase,WebofScience,和CochraneLibrary)用于研究从开始到2023年3月13日的p-iM的PDTCMD的随机对照试验(RCT)。采用RevMan5.4软件进行Meta分析。
结果:7项随机对照试验符合纳入标准。荟萃分析显示,PDT+CMD治疗在降低探查深度(PD)(平均差[MD]:-1.09,95%置信区间[CI]:-1.99至-0.2,P=0.02)和菌斑指数(PI)(MD:-2.06,95%CI:-2.81至-1.31,P<0.00001)方面比单独使用CMD更有效。然而,PDT+CMD组与CMD组之间探查出血(BOP)的改善无统计学意义(MD:-0.97,95%CI:-2.81至0.88,P=0.31)。
结论:根据现有证据,这项荟萃分析表明,在p-iM治疗中,与单纯CMD相比,在CMD中加入PDT能显著改善PD和PI.然而,在改善BOP方面没有显著差异。