PDF(Pubmed)
Abstract：
This study compares the changes in Quantitative electroencephalography (QEEG), loudness dependence of auditory evoked potentials (LDAEP), and mismatch negativity (MMN) in the case of bipolar depression, mania, and euthymia in a single patient. the characteristic of QEEG in this patient with mixed depression was an increase in alpha; in mixed mania, there was little increase in alpha, and the decrease in delta, theta, and beta was noticeable. LDAEP increased more in the manic phase than in the depressive phase. In contrast, MMN decreased more in the manic than in the depressive phase. After remission of mania, QEEG, LDAEP, and MMN were re-measured. Compared with the manic phase, the decrease in delta, theta, and beta bands in the occipital, temporal, and parietal lobes improved significantly. The LDAEP decreased from LDAEP 1.67 to 0.97. However, in spite of the euthymic phase, MMN amplitude showed a further decrease, from -1.7 to -0.9. In conclusion, using QEEG, LDAEP, and MMN can help clinicians predict a patient\'s bipolar state and evaluate serotonin intensity and cognitive function, enabling customized treatment. However, there are still few consistent research results; therefore, there is a need to utilize a larger sample size.
摘要：
这项研究比较了定量脑电图（QEEG）的变化，听觉诱发电位(LDAEP)的响度依赖性，和不匹配的负（MMN）在双相抑郁的情况下，躁狂症,和一个病人的正常状态。该混合性抑郁症患者的QEEG特征是alpha增加；在混合性躁狂症中，阿尔法几乎没有增加，三角洲的减少，theta,β是明显的。LDAEP在躁狂期比在抑郁期增加更多。相比之下,躁狂期的MMN下降幅度大于抑郁期。躁狂症缓解后,QEEG,LDAEP,和MMN被重新测量。与躁狂期相比，三角洲的减少，theta,和枕骨的β带，temporal,顶叶明显改善。LDAEP从LDAEP1.67降至0.97。然而,尽管处于和谐阶段，MMN振幅显示进一步下降，从-1.7到-0.9。总之,使用QEEG，LDAEP,和MMN可以帮助临床医生预测患者的双相状态，评估5-羟色胺强度和认知功能，实现定制治疗。然而,仍然很少有一致的研究结果；因此，有必要利用更大的样本量。
