Abstract：
BACKGROUND: In the last three decades, minimally invasive liver resection has been replacing conventional open approach in liver surgery. More recently, developments in neoadjuvant chemotherapy have led to increased multidisciplinary management of colorectal liver metastases with both medical and surgical treatment modalities. However, the impact of neoadjuvant chemotherapy on the surgical outcomes of minimally invasive liver resections remains poorly understood.
METHODS: A multicenter, international, database of 4998 minimally invasive minor hepatectomy for colorectal liver metastases was used to compare surgical outcomes in patients who received neoadjuvant chemotherapy with surgery alone. To correct for baseline imbalance, propensity score matching, coarsened exact matching and inverse probability treatment weighting were performed.
RESULTS: 2546 patients met the inclusion criteria. After propensity score matching there were 759 patients in both groups and 383 patients in both groups after coarsened exact matching. Baseline characteristics were equal after both matching strategies. Neoadjuvant chemotherapy was not associated with statistically significant worse surgical outcomes of minimally invasive minor hepatectomy.
CONCLUSIONS: Neoadjuvant chemotherapy had no statistically significant impact on short-term surgical outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases.
METHODS: A multicenter, international, database of 4998 minimally invasive minor hepatectomy for colorectal liver metastases was used to compare surgical outcomes in patients who received neoadjuvant chemotherapy with surgery alone. To correct for baseline imbalance, propensity score matching, coarsened exact matching and inverse probability treatment weighting were performed.
RESULTS: 2546 patients met the inclusion criteria. After propensity score matching there were 759 patients in both groups and 383 patients in both groups after coarsened exact matching. Baseline characteristics were equal after both matching strategies. Neoadjuvant chemotherapy was not associated with statistically significant worse surgical outcomes of minimally invasive minor hepatectomy.
CONCLUSIONS: Neoadjuvant chemotherapy had no statistically significant impact on short-term surgical outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases.
摘要：
背景：在过去的三十年中，在肝脏外科中，微创肝切除术已取代传统的开放入路。最近,新辅助化疗的发展导致通过内科和外科两种治疗方式对结直肠癌肝转移的多学科管理增加.然而,新辅助化疗对微创肝切除术手术结局的影响尚不清楚.
方法：多中心，国际,在接受新辅助化疗和单纯手术治疗的患者中,我们使用了4998例针对结直肠癌肝转移的微创肝切除术数据库,比较了手术结局.要纠正基线不平衡，倾向得分匹配，进行粗化精确匹配和逆概率处理加权。
结果：2546例患者符合纳入标准。倾向评分匹配后，两组均有759例患者，粗化精确匹配后两组均有383例患者。两种匹配策略后的基线特征相等。新辅助化疗与微创小肝切除术的手术效果无统计学意义。
结论：新辅助化疗对结直肠癌肝转移的简单和复杂微创小肝切除术后的短期手术效果无统计学意义。
方法：多中心，国际,在接受新辅助化疗和单纯手术治疗的患者中,我们使用了4998例针对结直肠癌肝转移的微创肝切除术数据库,比较了手术结局.要纠正基线不平衡，倾向得分匹配，进行粗化精确匹配和逆概率处理加权。
结果：2546例患者符合纳入标准。倾向评分匹配后，两组均有759例患者，粗化精确匹配后两组均有383例患者。两种匹配策略后的基线特征相等。新辅助化疗与微创小肝切除术的手术效果无统计学意义。
结论：新辅助化疗对结直肠癌肝转移的简单和复杂微创小肝切除术后的短期手术效果无统计学意义。
