{Reference Type}: Journal Article
{Title}: Impact of neoadjuvant chemotherapy on short-term outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases: A propensity-score matched and coarsened exact matched study.
{Author}: Hoogteijling TJ;Abu Hilal M;Zimmitti G;Aghayan DL;Wu AGR;Cipriani F;Gruttadauria S;Scatton O;Long TCD;Herman P;Marino MV;Mazzaferro V;Chiow AKH;Sucandy I;Ivanecz A;Choi SH;Lee JH;Gastaca M;Vivarelli M;Giuliante F;Ruzzenente A;Yong CC;Yin M;Fondevila C;Efanov M;Morise Z;Di Benedetto F;Brustia R;Dalla Valle R;Boggi U;Geller D;Belli A;Memeo R;Mejia A;Park JO;Rotellar F;Choi GH;Robles-Campos R;Wang X;Sutcliffe RP;Pratschke J;Tang CN;Chong CCN;D'Hondt M;Monden K;Lopez-Ben S;Kingham TP;Ferrero A;Ettorre GM;Cherqui D;Liang X;Soubrane O;Wakabayashi G;Troisi RI;Han HS;Cheung TT;Sugioka A;Dokmak S;Chen KH;Liu R;Fuks D;Zhang W;Aldrighetti L;Edwin B;Goh BKP; ;
{Journal}: Eur J Surg Oncol
{Volume}: 50
{Issue}: 6
{Year}: 2024 Jun 2
{Factor}: 4.037
{DOI}: 10.1016/j.ejso.2024.108309
{Abstract}: <B>BACKGROUND: </B>In the last three decades, minimally invasive liver resection has been replacing conventional open approach in liver surgery. More recently, developments in neoadjuvant chemotherapy have led to increased multidisciplinary management of colorectal liver metastases with both medical and surgical treatment modalities. However, the impact of neoadjuvant chemotherapy on the surgical outcomes of minimally invasive liver resections remains poorly understood.<BR><B>METHODS: </B>A multicenter, international, database of 4998 minimally invasive minor hepatectomy for colorectal liver metastases was used to compare surgical outcomes in patients who received neoadjuvant chemotherapy with surgery alone. To correct for baseline imbalance, propensity score matching, coarsened exact matching and inverse probability treatment weighting were performed.<BR><B>RESULTS: </B>2546 patients met the inclusion criteria. After propensity score matching there were 759 patients in both groups and 383 patients in both groups after coarsened exact matching. Baseline characteristics were equal after both matching strategies. Neoadjuvant chemotherapy was not associated with statistically significant worse surgical outcomes of minimally invasive minor hepatectomy.<BR><B>CONCLUSIONS: </B>Neoadjuvant chemotherapy had no statistically significant impact on short-term surgical outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases.