PDF(Pubmed)
Abstract：
OBJECTIVE: This review summarizes evidence on osteocyte support of extramedullary and bone marrow adipocyte development and discusses the role of endogenous osteocyte activities of nuclear receptors peroxisome proliferator-activated receptor gamma (PPARG) and alpha (PPARA) in this support.
RESULTS: PPARG and PPARA proteins, key regulators of glucose and fatty acid metabolism, are highly expressed in osteocytes. They play significant roles in the regulation of osteocyte secretome and osteocyte bioenergetics; both activities contributing to the levels of systemic energy metabolism in part through an effect on metabolic function of extramedullary and bone marrow adipocytes. The PPARs-controlled osteocyte endocrine/paracrine activities, including sclerostin expression, directly regulate adipocyte function, while the PPARs-controlled osteocyte fuel utilization and oxidative phosphorylation contribute to the skeletal demands for glucose and fatty acids, whose availability is under the control of adipocytes. Bone is an inherent element of systemic energy metabolism with PPAR nuclear receptors regulating osteocyte-adipocyte metabolic axes.
RESULTS: PPARG and PPARA proteins, key regulators of glucose and fatty acid metabolism, are highly expressed in osteocytes. They play significant roles in the regulation of osteocyte secretome and osteocyte bioenergetics; both activities contributing to the levels of systemic energy metabolism in part through an effect on metabolic function of extramedullary and bone marrow adipocytes. The PPARs-controlled osteocyte endocrine/paracrine activities, including sclerostin expression, directly regulate adipocyte function, while the PPARs-controlled osteocyte fuel utilization and oxidative phosphorylation contribute to the skeletal demands for glucose and fatty acids, whose availability is under the control of adipocytes. Bone is an inherent element of systemic energy metabolism with PPAR nuclear receptors regulating osteocyte-adipocyte metabolic axes.
摘要：
目的：这篇综述总结了骨细胞支持髓外和骨髓脂肪细胞发育的证据，并讨论了核受体过氧化物酶体增殖物激活受体γ（PPARG）和α（PPARA）的内源性骨细胞活性在这种支持中的作用。
结果：PPARG和PPARA蛋白，葡萄糖和脂肪酸代谢的关键调节剂，在骨细胞中高度表达。它们在调节骨细胞分泌体和骨细胞生物能中起重要作用；这两种活性部分通过对髓外和骨髓脂肪细胞的代谢功能的影响而导致系统能量代谢水平。PPARs控制的骨细胞内分泌/旁分泌活动，包括硬化蛋白的表达，直接调节脂肪细胞功能，而PPARs控制的骨细胞燃料利用和氧化磷酸化有助于骨骼对葡萄糖和脂肪酸的需求，其可用性在脂肪细胞的控制下。骨是全身能量代谢的固有元素，PPAR核受体调节骨细胞-脂肪细胞代谢轴。
结果：PPARG和PPARA蛋白，葡萄糖和脂肪酸代谢的关键调节剂，在骨细胞中高度表达。它们在调节骨细胞分泌体和骨细胞生物能中起重要作用；这两种活性部分通过对髓外和骨髓脂肪细胞的代谢功能的影响而导致系统能量代谢水平。PPARs控制的骨细胞内分泌/旁分泌活动，包括硬化蛋白的表达，直接调节脂肪细胞功能，而PPARs控制的骨细胞燃料利用和氧化磷酸化有助于骨骼对葡萄糖和脂肪酸的需求，其可用性在脂肪细胞的控制下。骨是全身能量代谢的固有元素，PPAR核受体调节骨细胞-脂肪细胞代谢轴。
