Abstract：
The purpose of this review is to highlight transformative advances that have been made in the field of biomolecular condensates, with special emphasis on condensate material properties, physiology, and kinases, using the With-No-Lysine (WNK) kinases as a prototypical example. To convey how WNK kinases illustrate important concepts for biomolecular condensates, we start with a brief history, focus on defining features of biomolecular condensates, and delve into some examples of how condensates are implicated in cellular physiology (and pathophysiology). We then highlight how WNK kinases, through the action of \"WNK droplets\" that ubiquitously regulate intracellular volume and kidney-specific \"WNK bodies\" that are implicated in distal tubule salt reabsorption and potassium homeostasis, exemplify many of the defining features of condensates. Finally, this review addresses the controversies within this emerging field and questions to address.
摘要：
这篇综述的目的是强调在生物分子缩合物领域取得的变革性进展，特别强调缩合物的性质，生理学,和激酶，使用无赖氨酸(WNK)激酶作为原型示例。为了传达WNK激酶如何说明生物分子缩合物的重要概念，我们从简短的历史开始，专注于定义生物分子缩合物的特征，并深入研究凝聚物如何参与细胞生理学（和病理生理学）的一些例子。然后我们强调WNK激酶，通过广泛调节细胞内体积的“WNK液滴”的作用，和肾脏特异性的“WNK体”涉及远端小管盐重吸收和钾稳态，举例说明了冷凝物的许多定义特征。最后,这项审查将解决这一新兴领域的争议和需要解决的问题。
