Abstract：
BACKGROUND: Chronic eosinophilic leukemia (CEL) is a rare invasive disease characterized by non-specific cytogenetic abnormalities or elevated mother cells, poor prognosis, and a high risk of conversion to acute leukemia.
METHODS: We described the data of a patient with CEL-NOS.
RESULTS: This case is a CEL-NOS with four mutations in CSF3R-T618I, DNMT3A Q816, ASXL1, and IDH2.
CONCLUSIONS: The patient rapidly evolves into secondary acute myeloid leukemia (AML).
METHODS: We described the data of a patient with CEL-NOS.
RESULTS: This case is a CEL-NOS with four mutations in CSF3R-T618I, DNMT3A Q816, ASXL1, and IDH2.
CONCLUSIONS: The patient rapidly evolves into secondary acute myeloid leukemia (AML).
摘要：
背景：慢性嗜酸性粒细胞白血病（CEL）是一种罕见的侵袭性疾病，其特征是非特异性细胞遗传学异常或母细胞升高，预后不良,和转化为急性白血病的高风险。
方法：我们描述了CEL-NOS患者的数据。
结果：本病例为CEL-NOS，CSF3R-T618I有4个突变，DNMT3AQ816、ASXL1和IDH2。
结论：患者迅速发展为继发性急性髓性白血病（AML）。
方法：我们描述了CEL-NOS患者的数据。
结果：本病例为CEL-NOS，CSF3R-T618I有4个突变，DNMT3AQ816、ASXL1和IDH2。
结论：患者迅速发展为继发性急性髓性白血病（AML）。
