PDF(Pubmed)
Abstract：
Pregnancy-associated breast cancer (PABC) presents unique challenges due to its occurrence during or shortly after pregnancy. Pregnancy-associated plasma protein A (PAPP-A) has emerged as a potential biomarker and regulator in PABC. This comprehensive review examines the role of PAPP-A in PABC, highlighting its involvement in tissue remodeling and cancer progression. Molecular mechanisms linking PAPP-A to breast cancer, including signaling pathways and interactions with other molecules, are explored. The review also discusses the diagnostic and therapeutic implications of PAPP-A dysregulation in PABC, emphasizing the need for further research to elucidate underlying mechanisms and develop targeted therapies. Collaborative efforts among researchers, clinicians, and industry stakeholders are essential for translating findings into clinically relevant interventions to improve outcomes for PABC patients.
摘要：
妊娠相关乳腺癌（PABC）由于其在怀孕期间或之后不久的发生而提出了独特的挑战。妊娠相关血浆蛋白A（PAPP-A）已成为PABC的潜在生物标志物和调节剂。这篇全面的综述探讨了PAPP-A在PABC中的作用，强调其参与组织重塑和癌症进展。将PAPP-A与乳腺癌联系起来的分子机制，包括信号通路和与其他分子的相互作用，正在探索。该综述还讨论了PABC中PAPP-A失调的诊断和治疗意义，强调需要进一步研究以阐明潜在机制并开发靶向治疗。研究人员之间的合作努力，临床医生,和行业利益相关者对于将研究结果转化为临床相关干预措施以改善PABC患者的预后至关重要。
