PDF(Pubmed)
Abstract：
BACKGROUND: Maxillary sinus squamous cell carcinoma (MS-SCC) is an infrequent malignancy, and determining the optimal neck management for patients with cT3/4N0 MS-SCC remains a topic of ongoing debate. The purpose of this study was to compare the prognoses and quality of life outcomes of patients who underwent either elective neck dissection (END) or elective neck irradiation (ENI) for cT3/4N0 MS-SCC.
METHODS: In this retrospective study, we enrolled patients with surgically treated cT3/4N0 MS-SCC, and the impact of different neck management strategies on regional control and disease-specific survival was compared using propensity score matching. The effect of surgical intervention on quality of life was evaluated using the Mann-Whitney U test.
RESULTS: Of the 120 patients included, 36 underwent END. After propensity score matching, our analysis indicated that END did not lead to superior outcomes than ENI, as demonstrated by comparable rates of regional control (p = 0.990) and disease-specific survival (p = 0.999). However, in the 70 returned questionnaires, patients who underwent END reported higher scores in the domains of appearance, chewing, and speech than did patients who underwent ENI.
CONCLUSIONS: Our findings suggest that while END and ENI contribute to similar prognoses, END yields superior functional outcomes.
METHODS: In this retrospective study, we enrolled patients with surgically treated cT3/4N0 MS-SCC, and the impact of different neck management strategies on regional control and disease-specific survival was compared using propensity score matching. The effect of surgical intervention on quality of life was evaluated using the Mann-Whitney U test.
RESULTS: Of the 120 patients included, 36 underwent END. After propensity score matching, our analysis indicated that END did not lead to superior outcomes than ENI, as demonstrated by comparable rates of regional control (p = 0.990) and disease-specific survival (p = 0.999). However, in the 70 returned questionnaires, patients who underwent END reported higher scores in the domains of appearance, chewing, and speech than did patients who underwent ENI.
CONCLUSIONS: Our findings suggest that while END and ENI contribute to similar prognoses, END yields superior functional outcomes.
摘要：
背景：上颌窦鳞状细胞癌（MS-SCC）是一种罕见的恶性肿瘤，确定cT3/4N0MS-SCC患者的最佳颈部管理方法仍然是一个正在进行辩论的话题。这项研究的目的是比较cT3/4N0MS-SCC接受选择性颈淋巴结清扫术（END）或选择性颈照射（ENI）的患者的预后和生活质量。
方法：在这项回顾性研究中，我们招募了接受手术治疗的cT3/4N0MS-SCC患者，使用倾向评分匹配比较了不同颈部管理策略对区域控制和疾病特异性生存率的影响.使用Mann-WhitneyU检验评估手术干预对生活质量的影响。
结果：在纳入的120例患者中，36结束。在倾向得分匹配后，我们的分析表明END没有导致优于ENI的结果，区域控制率（p=0.990）和疾病特异性生存率（p=0.999）证明了这一点。然而,在70份退回的问卷中，接受END的患者报告在外观领域得分较高，咀嚼,和言语比接受ENI的患者。
结论：我们的研究结果表明，尽管END和ENI有助于相似的预后，END产生优越的功能结果。
方法：在这项回顾性研究中，我们招募了接受手术治疗的cT3/4N0MS-SCC患者，使用倾向评分匹配比较了不同颈部管理策略对区域控制和疾病特异性生存率的影响.使用Mann-WhitneyU检验评估手术干预对生活质量的影响。
结果：在纳入的120例患者中，36结束。在倾向得分匹配后，我们的分析表明END没有导致优于ENI的结果，区域控制率（p=0.990）和疾病特异性生存率（p=0.999）证明了这一点。然而,在70份退回的问卷中，接受END的患者报告在外观领域得分较高，咀嚼,和言语比接受ENI的患者。
结论：我们的研究结果表明，尽管END和ENI有助于相似的预后，END产生优越的功能结果。
