Fibrinolysis shut down in COVID-19 patients: Report on two severe cases with potential diagnostic and clinical relevance.

COVID - 19 患者的纤溶停止 ： 报告了两个具有潜在诊断和临床相关性的严重病例。

• 发表时间: 2020 Dec
• 来源期刊: Thromb Update
• DOI: 10.1016/j.tru.2020.100008
• PMID: 38620653
• 文章类型: Journal Article
• 作者列表: Bakchoul T,Hammer S,Lang P,Rosenberger P

关键词: COVID-19; CT, cloting time; Coagulation; EX-Test, extrinsic test; Fibrinolysis; LT, lysis time; M, male; MCF, maximum clot firmness; ML, maximum clot lysis; PLT, platelet count; PT, prothrombin time; SOFA, Sepsis-related organ failure assessment score; TPA, tissue plasminogen activator; aPTT, activated partial thromboplastin time; y, years

Abstract

•To date most reports on COVID-19 associated coagulopathy focused an increased activation of the plasmatic coagulation system.•Using a novel method to assess clot lysis we observed abnormalities in fibrinolysis in COVID-19 infection.•Our finding suggests that fibrinolysis system may contribute to the procoagulatory status in COVID-19 patients.

摘要

•迄今为止，大多数关于COVID-19相关凝血病的报告都集中在血浆凝血系统激活增加。•使用一种新的方法来评估凝块溶解，我们观察到COVID-19感染中的纤维蛋白溶解异常。•我们的发现表明，纤溶系统可能有助于COVID-19患者的促凝状态。