Abstract：
Detergent chemistry enables applications in the world today while harming safe operating spaces that humanity needs for survival. Aim of this review is to support a holistic thought process in the design of detergent chemistry. We harness the planetary boundary concept as a framework for literature survey to identify progresses and knowledge gaps in context with detergent chemistry and five planetary boundaries that are currently transgressed, i.e., climate, freshwater, land system, novel entities, biosphere integrity. Our survey unveils the status of three critical challenges to be addressed in the years to come, including (i) the implementation of a holistically, climate-friendly detergent industry; (ii) the alignment of materialistic and social aspects in creating technical solutions by means of sustainable chemistry; (iii) the development of detergents that serve the purpose of applications but do not harm the biosphere in their role as novel entities. Specifically, medically relevant case reports revealed that even the most sophisticated detergent design cannot sufficiently accelerate drug discovery to outperform the antibiotic resistance development that detergents simultaneously promote as novel entities. Safe operating spaces that humanity needs for its survival may be secured by directing future efforts beyond sustainable chemistry, resource efficiency, and net zero emission targets.
摘要：
洗涤剂化学使当今世界的应用，同时损害人类生存所需的安全操作空间。这篇综述的目的是支持洗涤剂化学设计中的整体思维过程。我们利用行星边界概念作为文献调查的框架，以确定洗涤剂化学和当前违反的五个行星边界的背景下的进展和知识差距，即，气候,淡水,土地制度,新颖的实体，生物圈的完整性。我们的调查揭示了未来几年需要解决的三个关键挑战的现状，包括(I)全面实施，气候友好型洗涤剂工业；（ii）通过可持续化学手段创造技术解决方案的物质和社会方面的协调；（iii）开发用于应用目的但不损害生物圈作为新型实体的洗涤剂。具体来说,医学相关的案例报告显示，即使是最复杂的洗涤剂设计也无法充分加速药物发现，以胜过洗涤剂作为新实体同时促进的抗生素耐药性发展。人类生存所需的安全操作空间可以通过指导未来的努力来确保，超越可持续化学，资源效率，净零排放目标。
