Abstract：
The endoplasmic reticulum（ER）is the largest membranous network serving as a region for protein, lipid and steroid synthesis, transport and storage. Detailed information about ER-cisternae, ER-tubules and rough endoplasmic reticulum (rER) is scarce in human blood cells. This study describes a series of giant inclusions and Auer bodies in promyeloblasts in six patients with acute promyelocytic leukemia (APL), by light microscopy, transmission electron microscopy (TEM) and cytochemical stains. TEM revealed that giant inclusions and pro-Auer bodies were associated with rER and surrounded by tubular structures composed of degenerated or redundant membrane in promyeloblasts, which corresponded with elements of the ER system. This paper reveals that in the promyeloblasts of APL, ER is the source of and transforms progressively into giant inclusions and Auer bodies.
摘要：
内质网（ER）是蛋白质的最大膜状网络,脂质和类固醇合成，运输和储存。关于ER-cisternae的详细信息,人血细胞中的ER小管和粗面内质网（rER）很少。这项研究描述了六名急性早幼粒细胞白血病（APL）患者的成髓细胞中的一系列巨大内含物和Auer体，通过光学显微镜，透射电子显微镜（TEM）和细胞化学染色。TEM显示，巨大的包裹体和前奥尔体与rER相关，并被成纤维细胞中退化或冗余膜组成的管状结构包围，与ER系统的元素相对应。本文揭示了在APL的成髓细胞中，ER是巨大的夹杂物和奥尔体的来源，并逐渐转化为巨大的夹杂物和奥尔体。
