UNASSIGNED: The data of 675 preterm infants with gestational age ≤32 weeks, who were hospitalized in our neonatal intensive care unit, were obtained retrospectively from file records. The infants\' demographic characteristics, clinical findings, and weekly weight gain (g/kg/day) during the first 8 weeks were recorded. The univariate was used to examine the risk factors for ROP followed by multivariate regression.
UNASSIGNED: The incidence of ROP in the infants included in the study was 41% (n = 278) and 13.3% (n = 37) of them required treatment. In the infants of the group that developed ROP, the mean birth weight and gestational age were significantly lower than those in the group that did not develop ROP (973 ± 288 and 1301 ± 349 g, p = 0.001 and 28.48 ± 1.95 and 30.08 ± 1.60 weeks, p = 0.001, respectively). As the gestational week and birth weight decreased, ROP development and the risk of ROP-requiring treatment increased. In the infants of the group that developed ROP, the mean weight gain in the postnatal third week was detected as significantly lower compared to those in the group that did not develop ROP (13.9 ± 8.2 and 15.4 ± 6.8 g, p = 0.034). On multiple logistic regression analysis, birth weight (<750 g) (odds ratio [OR], 8.67; 95% confidence interval [CI], 3.99-18.82, p = 0.001), blood transfusion (OR, 2.39; 95% CI, 1.34-4.24, p = 0.003), necrotizing enterocolitis (OR, 4.79; 95% CI, 1.05-26.85, p = 0.045), bronchopulmonary dysplasia (OR, 2.03; 95% CI, 1.22-3.36, p = 0.006), antenatal steroid therapy (OR, 1.60; 95% CI, 1.05-2.43, p = 0.028), surfactant administration (OR, 2.06; 95% CI, 1.32-3.2, p = 0.001) were independent risk factors for ROP development.
UNASSIGNED: Postnatal weight gain may not be an accurate predictor of ROP development after adjusting for confounding factors. However, the analysis of independent risk factors that influenced the development of ROP revealed a statistically significant effect in cases of low birth weight, blood transfusion, necrotizing enterocolitis, bronchopulmonary dysplasia, and antenatal steroid and surfactant therapies. These findings may help ophthalmologists and neonatologists to pay special attention to this patient group during ROP scanning.
■675例胎龄≤32周的早产儿数据,他们在我们的新生儿重症监护室住院,是从档案记录中回顾性获得的。婴儿的人口统计学特征,临床发现,记录前8周的每周体重增加(g/kg/天)。单因素用于检查ROP的危险因素,然后进行多因素回归。
■纳入研究的婴儿中ROP的发生率为41%(n=278),其中13.3%(n=37)需要治疗。在患有ROP的组的婴儿中,平均出生体重和胎龄明显低于未发生ROP的组(973±288和1301±349g,p=0.001和28.48±1.95和30.08±1.60周,分别为p=0.001)。随着孕周和出生体重的下降,ROP发展和需要ROP治疗的风险增加。在患有ROP的组的婴儿中,与未发生ROP的组相比,产后第三周的平均体重增加显着降低(13.9±8.2和15.4±6.8g,p=0.034)。在多元logistic回归分析中,出生体重(<750克)(比值比[OR],8.67;95%置信区间[CI],3.99-18.82,p=0.001),输血(或,2.39;95%CI,1.34-4.24,p=0.003),坏死性小肠结肠炎(或,4.79;95%CI,1.05-26.85,p=0.045),支气管肺发育不良(或,2.03;95%CI,1.22-3.36,p=0.006),产前类固醇治疗(或,1.60;95%CI,1.05-2.43,p=0.028),表面活性剂给药(OR,2.06;95%CI,1.32-3.2,p=0.001)是ROP发展的独立危险因素。
■在校正混杂因素后,出生后体重增加可能不是ROP发展的准确预测因子。然而,对影响ROP发展的独立危险因素的分析显示,在低出生体重的情况下,输血,坏死性小肠结肠炎,支气管肺发育不良,和产前类固醇和表面活性剂治疗。这些发现可能有助于眼科医生和新生儿学家在ROP扫描过程中特别注意该患者组。