PDF(Pubmed)
Abstract：
UNASSIGNED: Schwannoma, a benign tumor originating from Schwann cells, is a rare case found intraorally. The tongue, palate and buccal mucosa are the most common sites of intraoral Schwannoma while it is very rarely found on the lips. Previous studies reported only twelve cases of Schwannoma on the upper lip. The etiology of Schwannoma is unknown, but in some literature, Schwannoma occurs due to a defect in the NF2 gene. Management of Schwannoma is excision of the capsule. The prognosis is good, and the recurrency is low. This article reports a rare case of upper lip Schwannoma in adolescent and its management with its histological, immunohistochemical and pathogenesis aspects.
METHODS: A 16-years old female presented a painless, semi-solid, mobile lump on the upper lip measuring of approximately 1.5 × 3 cm that had similar color with the surrounding tissue. The lump appeared 7 years ago.
UNASSIGNED: Excision of the capsule and margins of the tumor. Histopathological examination showed a unique feature of Schwannoma, the Verocay bodies. Subsequent immunohistochemical examination of S100 protein showed a classic type of Schwannoma.
CONCLUSIONS: Upper lip schwannoma is a very rare tumor, and this type of tumor cannot be distinguished from other benign soft tissue tumors based on clinical findings. Immunohistochemical results are in accordance with the Histopathological results for the final diagnosis of Schwannoma. Schwannoma can be used as a differential diagnosis in cases of lumps on the lips with sessile, similar color like surrounding tissue, painless, and movable features.
METHODS: A 16-years old female presented a painless, semi-solid, mobile lump on the upper lip measuring of approximately 1.5 × 3 cm that had similar color with the surrounding tissue. The lump appeared 7 years ago.
UNASSIGNED: Excision of the capsule and margins of the tumor. Histopathological examination showed a unique feature of Schwannoma, the Verocay bodies. Subsequent immunohistochemical examination of S100 protein showed a classic type of Schwannoma.
CONCLUSIONS: Upper lip schwannoma is a very rare tumor, and this type of tumor cannot be distinguished from other benign soft tissue tumors based on clinical findings. Immunohistochemical results are in accordance with the Histopathological results for the final diagnosis of Schwannoma. Schwannoma can be used as a differential diagnosis in cases of lumps on the lips with sessile, similar color like surrounding tissue, painless, and movable features.
摘要：
■神经鞘瘤，起源于雪旺氏细胞的良性肿瘤，是口腔内发现的罕见病例。舌头，腭和颊粘膜是口内神经鞘瘤最常见的部位，而在嘴唇上很少发现。先前的研究仅报道了12例上唇神经鞘瘤。神经鞘瘤的病因不明，但在一些文学作品中,神经鞘瘤的发生是由于NF2基因的缺陷。神经鞘瘤的治疗是切除胶囊。预后良好,复发率很低。本文报道了一例罕见的青少年上唇神经鞘瘤及其组织学治疗，免疫组织化学和发病机制方面。
方法：一名16岁女性表现出无痛，半固体,上唇上大约1.5×3厘米的移动肿块，与周围组织颜色相似。这个肿块出现在7年前。
■切除肿瘤的囊和边缘。组织病理学检查显示神经鞘瘤的独特特征，Verocay的尸体.随后对S100蛋白的免疫组织化学检查显示典型的神经鞘瘤类型。
结论：上唇神经鞘瘤是一种非常罕见的肿瘤，根据临床发现，这种类型的肿瘤不能与其他良性软组织肿瘤区分开来。免疫组织化学结果与最终诊断神经鞘瘤的组织病理学结果一致。神经鞘瘤可用于嘴唇上有无柄肿块的鉴别诊断，与周围组织的颜色相似，无痛,和可移动的功能。
方法：一名16岁女性表现出无痛，半固体,上唇上大约1.5×3厘米的移动肿块，与周围组织颜色相似。这个肿块出现在7年前。
■切除肿瘤的囊和边缘。组织病理学检查显示神经鞘瘤的独特特征，Verocay的尸体.随后对S100蛋白的免疫组织化学检查显示典型的神经鞘瘤类型。
结论：上唇神经鞘瘤是一种非常罕见的肿瘤，根据临床发现，这种类型的肿瘤不能与其他良性软组织肿瘤区分开来。免疫组织化学结果与最终诊断神经鞘瘤的组织病理学结果一致。神经鞘瘤可用于嘴唇上有无柄肿块的鉴别诊断，与周围组织的颜色相似，无痛,和可移动的功能。
