Abstract：
BACKGROUND: Among venous thromboembolism, pulmonary thromboembolism (PTE) is one of the most serious postoperative complications. Deep venous thrombosis (DVT) is the main cause. Considering the unknown prevalence of DVT and PTE in the postoperative period of cardiovascular surgery in Japan, we investigated the incidence in consecutive patients who underwent cardiovascular surgery.
METHODS: A total of 225 patients who underwent cardiovascular surgery at four hospitals consented to participate in the study. We assessed DVT using lower extremity venous ultrasound preoperatively and postoperatively. Seven patients with preexisting DVT were excluded. Postoperative antithrombotic therapy was administered at the discretion of the attending physician at each institution. The postoperative intermittent pneumatic compression therapy followed the standard prophylaxis protocol at each institution. Patients were grouped into DVT and non-DVT cohorts for comparison. Continuous variables were expressed as means ± standard deviations and compared by the t-test.
RESULTS: The analysis of lower extremity venous ultrasound images indicated that DVT developed in 16 of the 218 study patients (DVT, 7.3%). No patient had PTE. Procedure-related data revealed significantly higher total blood transfusion (DVT group: 61.2 ± 49.9 IU vs. non-DVT group: 27.7 ± 30.2 IU: p = 0.018, effect size = 1.048) in the DVT group. The multivariate logistic regression predictor of DVT based on preoperative, intraoperative, and postoperative factors was blood transfusion (p = 0.005, 95% confidence interval 1.010-1.059, odds ratio 1.034).
CONCLUSIONS: The incidence of postoperatively developed DVT was 7.3% in this study.
METHODS: A total of 225 patients who underwent cardiovascular surgery at four hospitals consented to participate in the study. We assessed DVT using lower extremity venous ultrasound preoperatively and postoperatively. Seven patients with preexisting DVT were excluded. Postoperative antithrombotic therapy was administered at the discretion of the attending physician at each institution. The postoperative intermittent pneumatic compression therapy followed the standard prophylaxis protocol at each institution. Patients were grouped into DVT and non-DVT cohorts for comparison. Continuous variables were expressed as means ± standard deviations and compared by the t-test.
RESULTS: The analysis of lower extremity venous ultrasound images indicated that DVT developed in 16 of the 218 study patients (DVT, 7.3%). No patient had PTE. Procedure-related data revealed significantly higher total blood transfusion (DVT group: 61.2 ± 49.9 IU vs. non-DVT group: 27.7 ± 30.2 IU: p = 0.018, effect size = 1.048) in the DVT group. The multivariate logistic regression predictor of DVT based on preoperative, intraoperative, and postoperative factors was blood transfusion (p = 0.005, 95% confidence interval 1.010-1.059, odds ratio 1.034).
CONCLUSIONS: The incidence of postoperatively developed DVT was 7.3% in this study.
摘要：
背景：在静脉血栓栓塞中，肺血栓栓塞症(PTE)是术后最严重的并发症之一。深静脉血栓（DVT）是主要病因。考虑到日本心血管手术术后DVT和PTE的患病率未知，我们调查了连续接受心血管手术的患者的发病率.
方法：共有225名在四家医院接受心血管手术的患者同意参与这项研究。我们在术前和术后使用下肢静脉超声评估DVT。排除了7例先前存在DVT的患者。术后抗血栓治疗由各机构的主治医师自行决定。术后间歇性充气加压治疗遵循每个机构的标准预防方案。将患者分为DVT和非DVT队列进行比较。连续变量表示为平均值±标准偏差，并通过t检验进行比较。
结果：对下肢静脉超声图像的分析表明，在218例研究患者中，有16例发生了DVT（DVT，7.3%）。没有患者有PTE。手术相关数据显示总输血量明显较高（DVT组：61.2±49.9IUvs.非DVT组：DVT组27.7±30.2IU：p=0.018，效应大小=1.048）。基于术前的DVT的多变量logistic回归预测因子,术中,术后因素为输血（p=0.005，95％置信区间1.010-1.059，比值比1.034）。
结论：本研究中术后发生DVT的发生率为7.3%。
方法：共有225名在四家医院接受心血管手术的患者同意参与这项研究。我们在术前和术后使用下肢静脉超声评估DVT。排除了7例先前存在DVT的患者。术后抗血栓治疗由各机构的主治医师自行决定。术后间歇性充气加压治疗遵循每个机构的标准预防方案。将患者分为DVT和非DVT队列进行比较。连续变量表示为平均值±标准偏差，并通过t检验进行比较。
结果：对下肢静脉超声图像的分析表明，在218例研究患者中，有16例发生了DVT（DVT，7.3%）。没有患者有PTE。手术相关数据显示总输血量明显较高（DVT组：61.2±49.9IUvs.非DVT组：DVT组27.7±30.2IU：p=0.018，效应大小=1.048）。基于术前的DVT的多变量logistic回归预测因子,术中,术后因素为输血（p=0.005，95％置信区间1.010-1.059，比值比1.034）。
结论：本研究中术后发生DVT的发生率为7.3%。
