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Abstract：
Extrauterine growth restriction (EUGR) has been used in the literature and clinical practice to describe inadequate growth in preterm infants. Significant variability is seen in the criteria for EUGR, with no standard definition reached to date. Moreover, no consensus on the optimal timing for assessment or the ideal growth monitoring tool has been achieved, and an ongoing debate persists on the appropriate terminology to express poor postnatal growth. To ensure an adequate understanding of growth and early intervention in preterm infants at higher risk, it is critical to relate the diagnostic criteria of EUGR to the ability to predict adverse outcomes, such as neurodevelopmental outcomes. This narrative review was conducted to present evidence that evaluates neurodevelopmental outcomes in preterm infants with EUGR, comparing separately the different definitions of this concept by weight (cross-sectional, longitudinal and \"true\" EUGR). In this article, we highlight the challenges of comparing various published studies on the subject, even when subclassifying by the definition of EUGR, due to the significant variability on the criteria used for each definition and for the evaluation of neurodevelopmental outcomes in different papers. This heterogeneity compromises the obtention of a single firm conclusion on the relation between different definitions of EUGR and adverse neurodevelopmental outcomes.
摘要：
宫外生长受限（EUGR）已在文献和临床实践中用于描述早产儿的生长不足。在EUGR的标准中可以看到显著的变异性，到目前为止还没有达到标准定义。此外，尚未就评估的最佳时机或理想的增长监测工具达成共识，和正在进行的辩论坚持适当的术语来表达出生后生长不良。为了确保对处于较高风险的早产儿的生长和早期干预有足够的了解，将EUGR的诊断标准与预测不良结局的能力联系起来至关重要，如神经发育结果。进行此叙述性综述是为了提供评估EUGR早产儿神经发育结局的证据。按权重分别比较这一概念的不同定义(横截面，纵向和“真实”EUGR)。在这篇文章中,我们强调了比较有关该主题的各种已发表研究的挑战，即使按照EUGR的定义进行细分，由于不同论文中用于每个定义和评估神经发育结局的标准存在显著差异。这种异质性损害了对EUGR不同定义与不良神经发育结局之间关系的单一坚定结论的获得。
