PDF(Pubmed)
Abstract：
Diterpenes represent one of the most diverse and structurally complex families of natural products. Among the myriad of diterpenoids, grayanane diterpenes are particularly notable. These terpenes are characterized by their unique 5/7/6/5 tetracyclic system and are exclusive to the Ericaceae family of plants. Renowned for their complex structures and broad spectrum of bioactivities, grayanane diterpenes have become a primary focus in extensive phytochemical and pharmacological research. Recent studies, spanning from 2018 to January 2024, have reported a series of new grayanane diterpenes with unprecedented carbon skeletons. These compounds exhibit various biological properties, including analgesic, antifeedant, anti-inflammatory, and inhibition of protein tyrosine phosphatase 1B (PTP1B). This paper delves into the discovery of 193 newly identified grayanoids, representing 15 distinct carbon skeletons within the Ericaceae family. The study of grayanane diterpenes is not only a deep dive into the complexities of natural product chemistry but also an investigation into potential therapeutic applications. Their unique structures and diverse biological actions make them promising candidates for drug discovery and medicinal applications. The review encompasses their occurrence, distribution, structural features, and biological activities, providing invaluable insights for future pharmacological explorations and research.
摘要：
二萜代表最多样化和结构复杂的天然产物家族之一。在无数的二萜中，特别值得注意的是灰烷二萜。这些萜烯的特征在于其独特的5/7/6/5四环系统,并且是菊科植物家族所独有的。以其复杂的结构和广泛的生物活性而闻名，grayanane二萜已成为广泛的植物化学和药理研究的主要焦点。最近的研究,从2018年到2024年1月，报告了一系列具有前所未有的碳骨架的新的灰烷烷二萜。这些化合物表现出各种生物学特性，包括镇痛药,拒食剂,抗炎,和抑制蛋白酪氨酸磷酸酶1B（PTP1B）。本文深入研究了193种新鉴定的类灰色化合物的发现，代表了赤霉科家族中15个不同的碳骨架。灰烷二萜的研究不仅是对天然产物化学复杂性的深入研究，而且是对潜在治疗应用的研究。它们独特的结构和多样的生物作用使它们成为药物发现和医学应用的有希望的候选者。审查包括它们的发生，分布，结构特征，和生物活动，为未来的药理学探索和研究提供宝贵的见解。
