PDF(Pubmed)
Abstract：
Gold nanoclusters (Au NCs) with bright emission and unique chemical reactivity characters have been widely applied for optical sensing and imaging. With a combination of surface modifications, effective therapeutic treatments of tumors are realized. In this review, we summarize the recently adopted biosensing and therapy events based on Au NCs. Homogeneous and fluorometric biosensing systems toward various targets, including ions, small molecules, reactive oxygen species, biomacromolecules, cancer cells, and bacteria, in vitro and in vivo, are presented by turn-off, turn-on, and ratiometric tactics. The therapy applications are concluded in three aspects: photodynamic therapy, photothermal therapy, and as a drug carrier. The basic mechanisms and performances of these systems are introduced. Finally, this review highlights the challenges and future trend of Au NC-based biosensing and therapy systems.
摘要：
金纳米团簇（AuNCs）具有明亮的发射和独特的化学反应性，已广泛应用于光学传感和成像。结合表面改性，实现了肿瘤的有效治疗。在这次审查中,我们总结了最近采用的基于AuNCs的生物传感和治疗事件。针对各种目标的均相和荧光生物传感系统，包括离子,小分子,活性氧，生物大分子，癌细胞,和细菌，在体外和体内，通过关闭呈现，打开,和比率策略。治疗应用总结为三个方面：光动力疗法，光热疗法,作为药物载体。介绍了这些系统的基本机制和性能。最后,这篇综述强调了基于AuNC的生物传感和治疗系统的挑战和未来趋势。
