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Abstract：
Background: Blue-yellow axis dyschromatopsia is well-known in Autosomal Dominant Optic Atrophy (ADOA) patients, but there were no data on the correlation between retinal structure and short-wavelength automated perimetry (SWAP) values in this pathology. Methods: In this cross-sectional case-control study, we assessed the correlation between best corrected visual acuity (BCVA), standard automated perimetry (SAP), SWAP, and optical coherence tomography (OCT) parameters of 9 ADOA patients compared with healthy controls. Correlation analysis was performed between BCVA, mean deviation, pattern standard deviation (PSD), and fovea sensitivity (FS) values and the OCT thickness of each retinal layer and the peripapillary retinal nerve fiber layer (pRNFL). Results: The following significant and strong correlations were found: between BCVA and ganglion cell layer (GCL) and the global (G) pRNFL thicknesses; between SAP FS and GCL and the G-pRNFL thicknesses; between SWAP PSD and total retina, GCL, inner plexiform layer, inner nuclear layer, inner retinal layer and the temporal pRNFL thicknesses. We found a constant shorter duration of the SITA-SWAP compared with the SITA-STANDARD strategy. Conclusions: SWAP, SAP, and BCVA values provided relevant clinical information about retinal involvement in our ADOA patients. The perimetric functional parameters that seemed to correlate better with structure involvement were FS on SAP and PSD on SWAP.
摘要：
背景：在常染色体显性视神经萎缩（ADOA）患者中，蓝黄色轴色谱分析障碍是众所周知的，但是在该病理中没有视网膜结构与短波长自动视野检查(SWAP)值之间相关性的数据.方法：在本横断面病例对照研究中，我们评估了最佳矫正视力(BCVA)之间的相关性，标准自动视野检查(SAP)，SWAP,9名ADOA患者的光学相干断层扫描（OCT）参数与健康对照相比。BCVA，平均偏差，模式标准偏差(PSD)，和中央凹敏感度（FS）值以及每个视网膜层和乳头周围视网膜神经纤维层（pRNFL）的OCT厚度。结果:BCVA与神经节细胞层(GCL)和整体(G)pRNFL厚度之间;SAPFS与GCL和G-pRNFL厚度之间;SWAP与总视网膜PSD之间,GCL,内丛状层，内部核层，视网膜内层和颞叶pRNFL厚度。与SITA标准策略相比，我们发现SITA-SWAP的持续时间持续较短。结论：SWAP，SAP,和BCVA值提供了有关ADOA患者视网膜受累的相关临床信息.似乎与结构参与相关更好的周边功能参数是SAP上的FS和SWAP上的PSD。
