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Abstract：
BACKGROUND: Depression is the common mental disease after stroke. Our objective was to investigate the correlation of Life\'s Essential 8 (LE8), the recently updated evaluation of cardiovascular health, with the occurrence of post-stroke depression (PSD) and all-cause mortality among United States (US) adults.
METHODS: Participants with stroke were chosen from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. The relationship between LE8 and the risk of PSD was assessed through weighted multiple logistic models. A restricted cubic spline was employed for the examination of correlations. To demonstrate the stability of the results, sensitivity analysis and subgroup analysis were carried out. Furthermore, Cox regression models were used for the correlation between LE8 and all-cause mortality.
RESULTS: In this study, a total of 1071 participants were included for analysis. It was observed that LE8 score and PSD risk shared an inverse relationship in per 10 points increase [OR = 0.62 (0.52-0.74, P < 0.001)] in logistic regression models. The analysis of restricted cubic spline demonstrated approximately a noticeable inverse linear association between LE8 score and PSD risk. Sensitivity analysis verified the stability of the findings. Moreover, no statistically significant interactions were identified in subgroup analysis. A reverse association between LE8 score and all-cause mortality was also observed with a 10-point increase [HR = 0.85 (0.78-0.94, P < 0.001)] in cox regression models.
CONCLUSIONS: A negative correlation was discovered between LE8 score and PSD and all-cause mortality risk among US adults. We need to conduct large-scale prospective studies to further validate our results.
METHODS: Participants with stroke were chosen from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. The relationship between LE8 and the risk of PSD was assessed through weighted multiple logistic models. A restricted cubic spline was employed for the examination of correlations. To demonstrate the stability of the results, sensitivity analysis and subgroup analysis were carried out. Furthermore, Cox regression models were used for the correlation between LE8 and all-cause mortality.
RESULTS: In this study, a total of 1071 participants were included for analysis. It was observed that LE8 score and PSD risk shared an inverse relationship in per 10 points increase [OR = 0.62 (0.52-0.74, P < 0.001)] in logistic regression models. The analysis of restricted cubic spline demonstrated approximately a noticeable inverse linear association between LE8 score and PSD risk. Sensitivity analysis verified the stability of the findings. Moreover, no statistically significant interactions were identified in subgroup analysis. A reverse association between LE8 score and all-cause mortality was also observed with a 10-point increase [HR = 0.85 (0.78-0.94, P < 0.001)] in cox regression models.
CONCLUSIONS: A negative correlation was discovered between LE8 score and PSD and all-cause mortality risk among US adults. We need to conduct large-scale prospective studies to further validate our results.
摘要：
背景：抑郁症是脑卒中后常见的精神疾病。我们的目的是调查生命本质8(LE8)的相关性，最近更新的心血管健康评估，在美国（US）成年人中发生卒中后抑郁（PSD）和全因死亡率。
方法：从2005年至2018年的国家健康和营养调查（NHANES）中选择中风的参与者。通过加权多Logistic模型评估LE8与PSD风险之间的关系。使用有限的三次样条来检查相关性。为了证明结果的稳定性，进行敏感性分析和亚组分析。此外，Cox回归模型用于LE8与全因死亡率之间的相关性。
结果：在这项研究中，共纳入1,071名参与者进行分析.在逻辑回归模型中，LE8评分与PSD风险呈负相关关系，每增加10分[OR=0.62（0.52-0.74，P<0.001）]。受限三次样条的分析表明，LE8评分与PSD风险之间存在明显的反线性相关。敏感性分析验证了研究结果的稳定性。此外，在亚组分析中未发现有统计学意义的交互作用.在cox回归模型中，LE8评分与全因死亡率之间也存在反向关联，增加10分[HR=0.85（0.78-0.94，P<0.001）]。
结论：在美国成年人中，LE8评分和PSD与全因死亡风险呈负相关。我们需要进行大规模的前瞻性研究来进一步验证我们的结果。
方法：从2005年至2018年的国家健康和营养调查（NHANES）中选择中风的参与者。通过加权多Logistic模型评估LE8与PSD风险之间的关系。使用有限的三次样条来检查相关性。为了证明结果的稳定性，进行敏感性分析和亚组分析。此外，Cox回归模型用于LE8与全因死亡率之间的相关性。
结果：在这项研究中，共纳入1,071名参与者进行分析.在逻辑回归模型中，LE8评分与PSD风险呈负相关关系，每增加10分[OR=0.62（0.52-0.74，P<0.001）]。受限三次样条的分析表明，LE8评分与PSD风险之间存在明显的反线性相关。敏感性分析验证了研究结果的稳定性。此外，在亚组分析中未发现有统计学意义的交互作用.在cox回归模型中，LE8评分与全因死亡率之间也存在反向关联，增加10分[HR=0.85（0.78-0.94，P<0.001）]。
结论：在美国成年人中，LE8评分和PSD与全因死亡风险呈负相关。我们需要进行大规模的前瞻性研究来进一步验证我们的结果。
