METHODS: Data came from a prospective pregnancy and birth cohort (N = 207, Cincinnati, OH). With multiple informant models, we estimated associations of prenatal (mean of 16 and 26 weeks of gestation maternal serum cotinine concentrations) and early childhood cotinine (average concentration across ages 12, 24, 36, and 48 months) with eating behaviors at age 12 years (Child Eating Behaviors Questionnaire). We tested whether associations differed by exposure periods and adolescent\'s sex. Models adjusted for maternal and child covariates.
RESULTS: We found no statistically significant associations between cotinine measures and adolescent\'s eating behaviors. Yet, in females, prenatal cotinine was associated with greater food responsiveness (β: 0.23; 95% CI: 0.08, 0.38) and lower satiety responsiveness (β: -0.14; 95% CI: -0.26, -0.02); in males, prenatal and postnatal cotinine was related to lower food responsiveness (prenatal: β: -0.25; 95% CI: -0.04, -0.06; postnatal: β: -0.36; 95% CI: -0.06, -0.11). No significant effect modification by sex or exposure window was found for other eating behaviors.
CONCLUSIONS: Prenatal and early childhood SHS exposures were not related to adolescent\'s eating behavior in this cohort; however, biological sex may modify these associations.
方法:数据来自前瞻性妊娠和出生队列(N=207,辛辛那提,OH).有了多个线人模型,我们估计了产前(妊娠16周和26周孕妇血清可替宁的平均浓度)和儿童早期可替宁(12,24,36和48个月的平均浓度)与12岁时饮食行为的相关性(儿童饮食行为问卷).我们测试了是否因暴露时间和青少年性别而存在关联差异。针对母婴协变量调整的模型。
结果:我们发现可替宁指标与青少年饮食行为之间没有统计学上的显著关联。然而,在女性中,产前可替宁与更高的食物反应性(β:0.23;95%CI:0.08,0.38)和更低的饱腹感反应性(β:-0.14;95%CI:-0.26,-0.02)相关;在男性中,产前和产后可替宁与食物反应性降低相关(产前:β:-0.25;95%CI:-0.04,-0.06;产后:β:-0.36;95%CI:-0.06,-0.11)。对于其他饮食行为,没有发现性别或暴露窗口的显着影响。
结论:在该队列中,产前和儿童早期SHS暴露与青少年的饮食行为无关;然而,生物性别可能会改变这些关联。