Abstract：
Objective - to study the Cardioprotective effect of Glycyrriza glabra ethanolic extract and Glycyrrhiza glabra Silver nanoparticle against alloxan and nicotinamide-induced diabetic cardiac injury in adult female Rats. The current study was performed on 36 days in which the G. glabra extract and G. glabra extract loaded on Silver nanoparticles were given to alloxan and nicotinamide-induced diabetic cardiac injured rats. The Cardioprotective effect has been evaluated biochemically. The results of induction of diabetic cardiac injury for 36 days showed a significantly increased (P˂0.05) serum Cardiac Troponin I (cTn-I) and Creatine Kinase (CK-MB) concentration in the diabetic cardiac injury induced (G2) group when compared with the control group (G1), and showed a significant decrease (P˂0.05) in the serum cTn-I and CK-MB concentration in (G3) group (received G. glabra extract) and (G4) group (G.glabra loaded on silver nanoparticle) in comparison with G2. This study concluded that Glycyrriza glabra extract and Glycyrrhiza glabra Silver nanoparticle have a significant Cardioprotective effect induced by alloxan and nicotinamide.
摘要：
目的研究甘草乙醇提取物和甘草银纳米颗粒对四氧嘧啶和烟酰胺诱导的成年雌性大鼠糖尿病心脏损伤的保护作用。当前的研究是在36天进行的，其中将装载在银纳米颗粒上的G.glabra提取物和G.glabra提取物给予四氧嘧啶和烟酰胺诱导的糖尿病心脏损伤大鼠。对心脏保护作用进行了生化评价。与对照组(G1)相比,糖尿病心脏损伤诱导组(G2)血清肌钙蛋白I(cTn-I)和肌酸激酶(CK-MB)浓度显著升高(P<0.05),（G3）组（接受G.glabra提取物）和（G4）组（G.）血清cTn-I和CK-MB浓度显着降低（P<0.05）。与G2相比，负载在银纳米颗粒上的glabra）。本研究得出结论，甘草提取物和甘草银纳米颗粒具有明显的四氧嘧啶和烟酰胺诱导的心脏保护作用。
