Abstract：
In view of a continuous trend in replacing synthetic feed additives and especially flavouring compounds by botanical preparations, different aspects of the safety evaluations of plants and plant-derived preparations and components in feed are discussed. This includes risk assessment approaches developed by the European Food Safety Authority (EFSA) for phytotoxins regarding unintentional exposure of target animals and of consumers to animal derived food via carry-over from feed. Relevant regulatory frameworks for feed additives and feed contaminants in the European Union are summarised and the essentials of existing guidelines used in the safety evaluation of botanicals and their preparations and components in feed are outlined. The examples presented illustrate how the safety of the botanicals, their preparations and components present in feed is assessed. An outlook on possible future developments in risk assessment by applying new in vitro and in silico methodologies is given.
摘要：
鉴于植物制剂不断替代合成饲料添加剂，尤其是调味化合物的趋势，讨论了植物和植物源性制剂和饲料中成分的安全性评估的不同方面。这包括由欧洲食品安全局(EFSA)开发的关于目标动物和消费者通过从饲料中结转而无意暴露于动物衍生食品的植物毒素的风险评估方法。概述了欧盟饲料添加剂和饲料污染物的相关监管框架，并概述了植物药及其制剂和饲料成分安全性评估中使用的现有指南的要点。所提供的例子说明了植物药的安全性，评估其制剂和存在于饲料中的成分。通过应用新的体外和计算机模拟方法，对风险评估的未来发展进行了展望。
