Abstract：
Human respiratory syncytial virus (RSV) is a common cause of respiratory infections in infants, young children, and elderly people. However, there are no effective treatments or vaccines available in most countries. In this study, we explored the anti-RSV potential of 2, 4-Di-tert-butylphenol (2, 4-DTBP), a compound derived from Houttuynia cordata Thunb. To overcome the poor solubility of 2, 4-DTBP, we encapsulated it in polymeric micelles and delivered it by inhalation. We found that 2, 4-DTBP-loaded micelles inhibited RSV infection in vitro and improved survival, lung pathology, and viral clearance in RSV-infected mice. Our results suggested that 2, 4-DTBP-loaded micelle is a promising novel therapeutic agent for RSV infection.
摘要：
人呼吸道合胞病毒（RSV）是婴儿呼吸道感染的常见原因，年幼的孩子,和老年人。然而,大多数国家没有有效的治疗或疫苗。在这项研究中,我们探索了2，4-二叔丁基苯酚（2，4-DTBP）的抗RSV潜力，一种来自鱼腥草的化合物。为了克服2，4-DTBP的溶解性差，我们将其封装在聚合物胶束中，并通过吸入递送。我们发现负载2,4-DTBP的胶束在体外抑制RSV感染并提高存活率,肺病理学,和RSV感染小鼠的病毒清除。我们的结果表明，负载2，4-DTBP的胶束是一种有前途的新型RSV感染治疗剂。
