巨噬细胞和癌细胞之间的串扰增强了胰腺癌恶病质。
关键词: CCL2 CCL5 RELB TWEAK cancer cachexia macrophages metabolic reprogramming muscle wasting p65 tumor microenvironment
Mesh : Cachexia / metabolism etiology pathology Pancreatic Neoplasms / metabolism pathology complications Cytokine TWEAK / metabolism Animals Humans Macrophages / metabolism Mice NF-kappa B / metabolism Cell Line, Tumor Tumor Microenvironment Muscular Atrophy / metabolism etiology pathology Chemokine CCL5 / metabolism Signal Transduction TNF Receptor-Associated Factor 6 / metabolism Tumor Necrosis Factors / metabolism Receptors, CCR2 / metabolism Chemokine CCL2 / metabolism Mice, Inbred C57BL
来 源:
DOI:10.1016/j.ccell.2024.03.009
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