PDF(Pubmed)
Abstract：
Observational research shows a link between celiac disease (CeD) and sarcoidosis, but the causal link between CeD and sarcoidosis is still unknown. A two-sample Mendelian randomization (MR) study was conducted to ascertain the causal connection between the 2 disorders. In our two-sample MR analysis, we identified independent genetic variants associated with CeD using publicly accessible GWAS data from people of European ancestry. Summary data for sarcoidosis were obtained from the FinnGen Consortium, the UK-Biobank, and a large GWAS dataset. To assess the association between CeD and sarcoidosis, our MR analysis used inverse variance weighted (IVW) as the primary method, incorporating the MR-Egger, weighted median (WM), and MR-PRESSO (outliers test) as a complementary method. In order to ensure that the findings were reliable, several sensitivity analyses were performed. Our study indicated that CeD had a significant causal relationship with sarcoidosis (IVW odds ratio (OR) = 1.13, 95% confidence interval (CI): 1.07-1.20, P = 5.58E-05; WM OR = 1.12, 95% CI: 1.03-1.23, P = 1.03E-02; MR-Egger OR = 1.07, 95% CI: 0.96-1.19, P = 2.20E-01). Additionally, we obtain the same results in the duplicated datasets as well, which makes our results even more reliable. The results of this investigation did not reveal any evidence of horizontal pleiotropy or heterogeneity. Our MR analysis showed a causal effect between CeD and an elevated risk of sarcoidosis. Further study is still needed to confirm the findings and look into the processes underlying these relationships.
摘要：
观察性研究表明乳糜泻（CeD）和结节病之间存在联系，但是CeD和结节病之间的因果关系仍然未知。进行了双样本孟德尔随机（MR）研究，以确定两种疾病之间的因果关系。在我们的双样本MR分析中，我们使用来自欧洲血统人群的可公开获取的GWAS数据鉴定了与CeD相关的独立遗传变异.结节病的汇总数据来自FinnGen联盟，英国生物银行，和一个大型GWAS数据集。为了评估CeD和结节病之间的关联，我们的MR分析使用逆方差加权(IVW)作为主要方法，合并MR-Egger，加权中位数(WM)，和MR-PRESSO(异常值测试)作为补充方法。为了确保调查结果可靠，进行了几项敏感性分析.我们的研究表明，CeD与结节病有显着的因果关系（IVW比值比（OR）=1.13，95％置信区间（CI）：1.07-1.20，P=5.58E-05；WMOR=1.12，95％CI：1.03-1.23，P=1.03E-02；MR-EggerOR=1.07，95％CI：0.96-1.19，P=2.2001此外,我们在复制的数据集中也获得了相同的结果，这使得我们的结果更加可靠。这项调查的结果没有发现任何水平多效性或异质性的证据。我们的MR分析显示CeD与结节病风险升高之间存在因果关系。仍然需要进一步的研究来确认这些发现并研究这些关系背后的过程。
