Abstract：
Autophagy is a conservative lysosome-dependent material catabolic pathway, and exists in all eukaryotic cells. Autophagy controls cell quality and survival by eliminating intracellular dysfunction substances, and plays an important role in various pathophysiology processes. Erectile dysfunction (ED) is a common male disease. It is resulted from a variety of causes and pathologies, such as diabetes, hypertension, hyperlipidemia, aging, spinal cord injury, or cavernous nerve injury caused by radical prostatectomy, and others. In the past decade, autophagy has begun to be investigated in ED. Subsequently, an increasing number of studies have revealed the regulation of autophagy contributes to the recovery of ED, and which is mainly involved in improving endothelial function, smooth muscle cell apoptosis, penile fibrosis, and corpus cavernosum nerve injury. Therefore, in this review, we aim to summarize the possible role of autophagy in ED from a cellular perspective, and we look forward to providing a new idea for the pathogenesis investigation and clinical treatment of ED in the future.
摘要：
自噬是一种保守的溶酶体依赖性物质分解代谢途径,并存在于所有真核细胞中。自噬通过消除细胞内功能障碍物质来控制细胞质量和存活，在各种病理生理过程中发挥着重要作用。勃起功能障碍（ED）是一种常见的男性疾病。它是由多种原因和病理导致的，比如糖尿病，高血压,高脂血症,老化，脊髓损伤,或根治性前列腺切除术引起的海绵状神经损伤，和其他人。在过去的十年里,自噬已经开始在ED中进行研究。随后，越来越多的研究表明，自噬的调节有助于ED的恢复，主要涉及改善内皮功能，平滑肌细胞凋亡，阴茎纤维化,和海绵体神经损伤。因此,在这次审查中,我们旨在从细胞角度总结自噬在ED中的可能作用，期待为今后ED的发病机制研究和临床治疗提供新的思路。
