Abstract：
Three new C10 and C12 aliphatic δ-lactones (1-3), three new fatty acid methyl esters (4-6), and eight known compounds (7-14) were isolated from the marine Aureobasidium sp. LUO5. Their structures were established by detailed analyses of the NMR, HRESIMS, optical rotation, and ECD data. All isolates were tested for their inhibitory effects on nitric oxide production in LPS-induced BV-2 cells. Notably, compound 4 displayed the strongest inhibitory effect with the IC50 value of 120.3 nM.
摘要：
三个新的C10和C12脂肪族δ-内酯（1-3），三种新的脂肪酸甲酯（4-6），和八种已知化合物（7-14）从海洋金黄色葡萄球菌中分离出来。LOO5它们的结构是通过NMR的详细分析来确定的，HRESIMS,旋光,和ECD数据。测试了所有分离株对LPS诱导的BV-2细胞中一氧化氮产生的抑制作用。值得注意的是,化合物4表现出最强的抑制作用,IC50值为120.3nM。
