%0 Journal Article
%T Chemical Constituents from the deep-sea-derived Fungus Aureobasidium melanogenum LUO5.
%A Dong HY
%A Wang Y
%A Zhang XY
%A Zhang M
%A Yang LH
%A Zou ZB
%A Li Y
%A Xie MM
%A Yang XW
%A Wang B
%J Chem Biodivers
%V 21
%N 6
%D 2024 Jun 12
%M 38606561
%F 2.745
%R 10.1002/cbdv.202400507
%X Three new C10 and C12 aliphatic δ-lactones (1-3), three new fatty acid methyl esters (4-6), and eight known compounds (7-14) were isolated from the marine Aureobasidium sp. LUO5. Their structures were established by detailed analyses of the NMR, HRESIMS, optical rotation, and ECD data. All isolates were tested for their inhibitory effects on nitric oxide production in LPS-induced BV-2 cells. Notably, compound 4 displayed the strongest inhibitory effect with the IC50 value of 120.3 nM.