PDF(Pubmed)
Abstract：
As the global incidence of idiopathic pulmonary fibrosis (IPF) is on the rise, there is a need for better diagnostic criteria, better treatment options, early and appropriate diagnosis, adequate care, and a multidisciplinary approach to the management of patients. This systematic review explores the role of proton pump inhibitors (PPIs) in IPF and answers the question, \"Does proton pump inhibitor improve only the prognosis of gastroesophageal associated idiopathic pulmonary fibrosis or for other types of idiopathic pulmonary fibrosis too?\" We used PubMed (PMC) and Google Scholar for data collection for this systematic review and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for conducting this review. After in-depth literature screening and quality appraisal, 12 articles were selected for this systematic review. On the one hand, the efficacy of PPI therapy is supported by research such as the CAPACITY and ASCEND trials, a pilot randomized control trial (RCT) investigating the role of omeprazole in IPF and a bidirectional two-sample Mendelian randomization (MR) study, respectively. On the other hand, a systematic review and meta-analysis on antacid and antireflux surgery in IPF negate these results and show no statistical significance. Questions regarding the efficacy of PPI therapy must be dealt with in an adequately powered multicenter and double-blinded randomized control trial. The anti-inflammatory properties of antacids can serve as the cornerstone for future trials. In the following systematic review, antacid, antireflux therapy, omeprazole, and proton pump therapy are synonymous with stomach acid suppression therapy.
摘要：
随着特发性肺纤维化(IPF)的全球发病率呈上升趋势,需要更好的诊断标准，更好的治疗选择，早期和适当的诊断，足够的照顾,和多学科的方法来管理病人。这篇系统的综述探讨了质子泵抑制剂（PPI）在IPF中的作用，并回答了这个问题。“质子泵抑制剂是否仅改善胃食管相关特发性肺纤维化或其他类型特发性肺纤维化的预后？”我们使用PubMed（PMC）和GoogleScholar收集本系统评价的数据，并遵循系统评价和荟萃分析的首选报告项目（PRISMA）指南进行本评价。经过深入的文献筛选和质量评价，本系统综述共选取12篇文章。一方面,PPI治疗的有效性得到了CAPACITY和ASCEND试验等研究的支持，一项研究奥美拉唑在IPF中作用的随机对照试验(RCT)和一项双向双样本孟德尔随机化(MR)研究,分别。另一方面,关于IPF抗酸和抗反流手术的系统评价和荟萃分析否定了这些结果,显示无统计学意义.关于PPI治疗的有效性的问题必须在足够有力的多中心和双盲随机对照试验中处理。抗酸剂的抗炎特性可以作为未来试验的基石。在下面的系统审查中，抗酸剂,抗反流治疗,奥美拉唑,质子泵治疗是胃酸抑制治疗的同义词。
