PDF(Pubmed)
Abstract：
UNASSIGNED: The degree to which sarcoidosis patients are affected by autoimmune diseases is poorly understood. Prior studies of autoimmune co-morbidities in sarcoidosis have focused on populations outside the USA or have been impeded by small sample sizes and limited scope. This case-control study evaluated the association between sarcoidosis and autoimmune diseases in a large, diverse cohort based in the USA.
UNASSIGNED: We used data from the All of Us research programme to conduct a case-control study involving patients ≥18 years old, from 2018 to the present, diagnosed with sarcoidosis. Sarcoidosis cases and age-, sex- and race-matched controls were identified in a 1:4 ratio. Autoimmune co-morbidities were compared between sarcoidosis patients and controls in univariable and multivariable analyses using logistic regression. The degree of association was measured using the odds ratio (OR).
UNASSIGNED: A total of 1408 sarcoidosis cases and 5632 controls were included in this study. Seven of 24 examined autoimmune diseases were significantly associated with sarcoidosis in our multivariable analysis (P < 0.05). The composite variable of any autoimmune disease was also significantly associated with sarcoidosis (OR = 2.29, P < 0.001).
UNASSIGNED: We demonstrate an association between sarcoidosis and multiple autoimmune diseases in a large and diverse cohort based in the USA. These results underscore the need for careful screening of sarcoidosis patients for concomitant autoimmune disease.
UNASSIGNED: We used data from the All of Us research programme to conduct a case-control study involving patients ≥18 years old, from 2018 to the present, diagnosed with sarcoidosis. Sarcoidosis cases and age-, sex- and race-matched controls were identified in a 1:4 ratio. Autoimmune co-morbidities were compared between sarcoidosis patients and controls in univariable and multivariable analyses using logistic regression. The degree of association was measured using the odds ratio (OR).
UNASSIGNED: A total of 1408 sarcoidosis cases and 5632 controls were included in this study. Seven of 24 examined autoimmune diseases were significantly associated with sarcoidosis in our multivariable analysis (P < 0.05). The composite variable of any autoimmune disease was also significantly associated with sarcoidosis (OR = 2.29, P < 0.001).
UNASSIGNED: We demonstrate an association between sarcoidosis and multiple autoimmune diseases in a large and diverse cohort based in the USA. These results underscore the need for careful screening of sarcoidosis patients for concomitant autoimmune disease.
摘要：
■结节病患者受自身免疫性疾病影响的程度知之甚少。结节病中自身免疫合并症的先前研究集中在美国以外的人群中，或者由于样本量小和范围有限而受到阻碍。这项病例对照研究评估了结节病与自身免疫性疾病之间的关联，基于美国的多样化队列。
■我们使用来自AllofUs研究计划的数据进行了一项涉及≥18岁患者的病例对照研究，从2018年到现在,诊断为结节病。结节病病例和年龄-，性别和种族匹配的对照以1:4的比例进行鉴定。在单变量和多变量分析中，使用逻辑回归比较结节病患者和对照组之间的自身免疫性合并症。使用比值比（OR）测量关联程度。
■本研究共纳入1408例结节病病例和5632例对照。在我们的多变量分析中，24例检查的自身免疫性疾病中有7例与结节病显着相关（P<0.05）。任何自身免疫性疾病的复合变量也与结节病显著相关(OR=2.29,P<0.001)。
■我们在美国一个庞大且多样化的队列中证明了结节病与多种自身免疫性疾病之间的关联。这些结果强调需要仔细筛查结节病患者并发自身免疫性疾病。
■我们使用来自AllofUs研究计划的数据进行了一项涉及≥18岁患者的病例对照研究，从2018年到现在,诊断为结节病。结节病病例和年龄-，性别和种族匹配的对照以1:4的比例进行鉴定。在单变量和多变量分析中，使用逻辑回归比较结节病患者和对照组之间的自身免疫性合并症。使用比值比（OR）测量关联程度。
■本研究共纳入1408例结节病病例和5632例对照。在我们的多变量分析中，24例检查的自身免疫性疾病中有7例与结节病显着相关（P<0.05）。任何自身免疫性疾病的复合变量也与结节病显著相关(OR=2.29,P<0.001)。
■我们在美国一个庞大且多样化的队列中证明了结节病与多种自身免疫性疾病之间的关联。这些结果强调需要仔细筛查结节病患者并发自身免疫性疾病。
