{Reference Type}: Journal Article
{Title}: Autoimmune comorbidities associated with sarcoidosis: a case-control study in the All of Us research program.
{Author}: Murphy MJ;Edemobi P;Leasure AC;Gulati M;Miller EJ;Damsky W;Cohen JM;
{Journal}: Rheumatol Adv Pract
{Volume}: 7
{Issue}: 2
{Year}: 2023
暂无{DOI}: 10.1093/rap/rkad030
{Abstract}: <B>UNASSIGNED: </B>The degree to which sarcoidosis patients are affected by autoimmune diseases is poorly understood. Prior studies of autoimmune co-morbidities in sarcoidosis have focused on populations outside the USA or have been impeded by small sample sizes and limited scope. This case-control study evaluated the association between sarcoidosis and autoimmune diseases in a large, diverse cohort based in the USA.<BR><B>UNASSIGNED: </B>We used data from the All of Us research programme to conduct a case-control study involving patients ≥18 years old, from 2018 to the present, diagnosed with sarcoidosis. Sarcoidosis cases and age-, sex- and race-matched controls were identified in a 1:4 ratio. Autoimmune co-morbidities were compared between sarcoidosis patients and controls in univariable and multivariable analyses using logistic regression. The degree of association was measured using the odds ratio (OR).<BR><B>UNASSIGNED: </B>A total of 1408 sarcoidosis cases and 5632 controls were included in this study. Seven of 24 examined autoimmune diseases were significantly associated with sarcoidosis in our multivariable analysis (P < 0.05). The composite variable of any autoimmune disease was also significantly associated with sarcoidosis (OR = 2.29, P < 0.001).<BR><B>UNASSIGNED: </B>We demonstrate an association between sarcoidosis and multiple autoimmune diseases in a large and diverse cohort based in the USA. These results underscore the need for careful screening of sarcoidosis patients for concomitant autoimmune disease.