PDF(Pubmed)
Abstract：
Juvenile Systemic Connective Tissue Diseases (JSCTD) are a heterogeneous group of chronic autoimmune diseases, associated with dyslipidemia and increased cardiovascular risk are related. Studies from the last 10 years, from 2013 to 2022, on lipid profiles in JSCTD were collected. Different studies on lipid profiles in children affected by JSCTD were selected, because the aim is to analyze the cardiovascular risk and the possibility of atherosclerosis in these patients in whom, sometimes, corticosteroid therapies and immunosuppressants increase the state of dyslipidemia. Several studies have shown that autoimmune diseases with an inflammatory substrate also share abnormalities in lipid profile and increased cardiovascular risk. Specifically, associations have been found between Juvenile Systemic Connective Tissue Diseases and elevated triglycerides, TC-C (Total Cholesterol), LDL-C (Low-Density Lipoprotein), low HDL-C (High-Density Lipoprotein), and increased risk of developing diseases such as myocardial infarction, peripheral vascular disease, pulmonary and arterial hypertension, and atrial fibrillation. Supplementation with alpha-linolenic acid (ALA) on the other hand has also been analyzed with positive results in reducing inflammatory parameters, such as IL-6 (Interleukin-6), CRP (C-reactive protein), and fasting glucose, in subjects with dyslipidemia. These observations suggest that supplementation with ALA, an omega-3 precursor, may positively modulate both the inflammatory status and dyslipidemic conditions in patients with autoimmune disorders.
摘要：
青少年系统性结缔组织病（JSCTD）是一组异质性的慢性自身免疫性疾病，与血脂异常和心血管风险增加相关。过去10年的研究,从2013年到2022年，收集了JSCTD中的血脂谱。选择了受JSCTD影响的儿童的血脂状况的不同研究，因为目的是分析这些患者的心血管风险和动脉粥样硬化的可能性，有时,皮质类固醇治疗和免疫抑制剂增加血脂异常的状态。一些研究表明，具有炎性底物的自身免疫性疾病也具有脂质分布异常和心血管风险增加。具体来说,已经发现青少年系统性结缔组织疾病和甘油三酯升高之间的关联，TC-C（总胆固醇），LDL-C（低密度脂蛋白），低HDL-C（高密度脂蛋白），并增加患心肌梗塞等疾病的风险，外周血管疾病,肺动脉高压,和心房颤动。另一方面，补充α-亚麻酸（ALA）也已被分析，在降低炎症参数方面具有积极的结果。如IL-6（白细胞介素-6），CRP(C反应蛋白),和空腹血糖，在血脂异常的受试者中。这些观察结果表明，补充ALA，omega-3前体,可以积极调节自身免疫性疾病患者的炎症状态和血脂异常。
