PDF(Pubmed)
Abstract：
BACKGROUND: There is limited information on the mixture effect and weights of light physical activity (LPA), moderate physical activity (MPA), and vigorous physical activity (VPA) on dementia risk.
METHODS: A prospective cohort study was conducted based on the UK Biobank dataset. We included participants aged at least 45 years old without dementia at baseline between 2006-2010. The weighted quantile sum regression was used to explore the mixture effect and weights of three types of physical activity on dementia risk.
RESULTS: This study includes 354,123 participants, with a mean baseline age of 58.0-year-old and 52.4 % of female participants. During a median follow-up time of 12.5 years, 5,136 cases of dementia were observed. The mixture effect of LPA, MPA, and VPA on dementia was statistically significant (β: -0.0924, 95 % Confidence Interval (CI): (-0.1402, -0.0446), P < 0.001), with VPA (weight: 0.7922) contributing most to a lower dementia risk, followed by MPA (0.1939). For Alzheimer\'s disease, MPA contributed the most (0.8555); for vascular dementia, VPA contributed the most (0.6271).
CONCLUSIONS: For Alzheimer\'s disease, MPA was identified as the most influential factor, while VPA stood out as the most impactful for vascular dementia.
METHODS: A prospective cohort study was conducted based on the UK Biobank dataset. We included participants aged at least 45 years old without dementia at baseline between 2006-2010. The weighted quantile sum regression was used to explore the mixture effect and weights of three types of physical activity on dementia risk.
RESULTS: This study includes 354,123 participants, with a mean baseline age of 58.0-year-old and 52.4 % of female participants. During a median follow-up time of 12.5 years, 5,136 cases of dementia were observed. The mixture effect of LPA, MPA, and VPA on dementia was statistically significant (β: -0.0924, 95 % Confidence Interval (CI): (-0.1402, -0.0446), P < 0.001), with VPA (weight: 0.7922) contributing most to a lower dementia risk, followed by MPA (0.1939). For Alzheimer\'s disease, MPA contributed the most (0.8555); for vascular dementia, VPA contributed the most (0.6271).
CONCLUSIONS: For Alzheimer\'s disease, MPA was identified as the most influential factor, while VPA stood out as the most impactful for vascular dementia.
摘要：
背景：关于轻度体力活动（LPA）的混合效应和重量的信息有限，适度的身体活动（MPA），和剧烈的体力活动（VPA）对痴呆症的风险。
方法：基于UKBiobank数据集进行前瞻性队列研究。我们纳入了2006-2010年间基线年龄至少45岁无痴呆的参与者。采用加权分位数和回归分析三种体力活动对痴呆风险的混合效应和权重。
结果：这项研究包括354,123名参与者，平均基线年龄为58.0岁，女性参与者占52.4%。在12.5年的中位随访时间内，观察到5,136例痴呆。LPA的混合效应，MPA,和VPA对痴呆有统计学意义（β：-0.0924，95％置信区间（CI）：（-0.1402，-0.0446），P<0.001)，VPA（体重：0.7922）对降低痴呆症风险的贡献最大，其次是MPA（0.1939）。对于阿尔茨海默病，MPA贡献最大(0.8555)；对于血管性痴呆，VPA贡献最大（0.6271）。
结论：对于阿尔茨海默病，MPA被确定为最具影响力的因素，而VPA对血管性痴呆最有影响。
方法：基于UKBiobank数据集进行前瞻性队列研究。我们纳入了2006-2010年间基线年龄至少45岁无痴呆的参与者。采用加权分位数和回归分析三种体力活动对痴呆风险的混合效应和权重。
结果：这项研究包括354,123名参与者，平均基线年龄为58.0岁，女性参与者占52.4%。在12.5年的中位随访时间内，观察到5,136例痴呆。LPA的混合效应，MPA,和VPA对痴呆有统计学意义（β：-0.0924，95％置信区间（CI）：（-0.1402，-0.0446），P<0.001)，VPA（体重：0.7922）对降低痴呆症风险的贡献最大，其次是MPA（0.1939）。对于阿尔茨海默病，MPA贡献最大(0.8555)；对于血管性痴呆，VPA贡献最大（0.6271）。
结论：对于阿尔茨海默病，MPA被确定为最具影响力的因素，而VPA对血管性痴呆最有影响。
