PDF(Pubmed)
Abstract：
Polymyxin-induced neuromuscular blockade is a rare but potentially fatal condition, with majority of cases that were reported between 1962 and 1973. We describe a patient who developed hypercapnic respiratory failure after initiation of polymyxin for multi-drug resistant Escherichia Coli bacteremia, due to polymyxin-induced neuromuscular dysfunction. After cessation of polymyxin, he regained full strength, had complete resolution of ptosis, and was successfully extubated. In light of the renewed use of polymyxin in this era of antimicrobial-resistance, this case aims to raise awareness about this rare but life-threatening condition, which is easily reversible with early recognition and prompt discontinuation of the drug.
摘要：
多粘菌素诱导的神经肌肉阻滞是一种罕见但可能致命的疾病，大多数病例是在1962年至1973年之间报告的。我们描述了一名在多粘菌素开始治疗多药耐药大肠杆菌菌血症后出现高碳酸血症性呼吸衰竭的患者，由于多粘菌素诱导的神经肌肉功能障碍。停止多粘菌素后，他恢复了全部的力量,完全解决了上睑下垂，并成功拔管。鉴于多粘菌素在抗生素耐药性时代的重新使用，此案旨在提高人们对这种罕见但危及生命的疾病的认识，这是很容易可逆的早期识别和迅速停药。
