PDF(Pubmed)
Abstract：
UNASSIGNED: In the second wave of COVID-19 pandemic, there has been an increase in number of cases with Post-COVID-19 fungal osteomyelitis of jaws. Aspergillosis was found to be one of the causes of osteomyelitis of jaw bones in these patients.
UNASSIGNED: To evaluate the incidence and pattern of osteomyelitis of jaw due to aspergillosis in post-COVID-19 patients and to discuss the management protocol of the same.
UNASSIGNED: Data were obtained at our institution from the period of January 2021 to June 2021. Patients of all age groups with Post-COVID-19 osteomyelitis of jaw due to aspergillosis and those with combined aspergillosis and mucormycosis infection were included. Patients having rhino-orbito-cerebral fungal infection were excluded.
UNASSIGNED: A total of 47 patients reported to our center. Demographically the average age of the patients was 49.11 years with 72% being males. All 47 patients (N = 100%) had received steroids. 21 of them (N = 44.7%) had diabetes mellitus and 14 (N = 29.8%) patients had other comorbidities. Out of 47 patients, 42 (N = 89.7%) patients were diagnosed with aspergillosis and the remaining 5 (N = 10.3%) cases had a mixed fungal infection of mucormycosis and aspergillosis. On fungal culture Aspergillus flavus was the most common species detected followed by Aspergillus niger and Aspergillus fumigatus. All patients were treated with oral Voriconazole and local surgical debridement. Prompt laboratory testing such as a timely KOH mount, galactomannan test, beta-D-glucan test, histopathology of tissue specimens could help to give an early and definitive diagnosis. The mortality rate we encountered in this study was nil.
UNASSIGNED: Early and definitive diagnosis and immediate initiation of antifungal drug therapy and surgical intervention will significantly reduce the rate of morbidity and mortality.
UNASSIGNED: To evaluate the incidence and pattern of osteomyelitis of jaw due to aspergillosis in post-COVID-19 patients and to discuss the management protocol of the same.
UNASSIGNED: Data were obtained at our institution from the period of January 2021 to June 2021. Patients of all age groups with Post-COVID-19 osteomyelitis of jaw due to aspergillosis and those with combined aspergillosis and mucormycosis infection were included. Patients having rhino-orbito-cerebral fungal infection were excluded.
UNASSIGNED: A total of 47 patients reported to our center. Demographically the average age of the patients was 49.11 years with 72% being males. All 47 patients (N = 100%) had received steroids. 21 of them (N = 44.7%) had diabetes mellitus and 14 (N = 29.8%) patients had other comorbidities. Out of 47 patients, 42 (N = 89.7%) patients were diagnosed with aspergillosis and the remaining 5 (N = 10.3%) cases had a mixed fungal infection of mucormycosis and aspergillosis. On fungal culture Aspergillus flavus was the most common species detected followed by Aspergillus niger and Aspergillus fumigatus. All patients were treated with oral Voriconazole and local surgical debridement. Prompt laboratory testing such as a timely KOH mount, galactomannan test, beta-D-glucan test, histopathology of tissue specimens could help to give an early and definitive diagnosis. The mortality rate we encountered in this study was nil.
UNASSIGNED: Early and definitive diagnosis and immediate initiation of antifungal drug therapy and surgical intervention will significantly reduce the rate of morbidity and mortality.
摘要：
■在COVID-19大流行的第二波中，COVID-19后颌骨真菌性骨髓炎的病例数量有所增加。曲霉菌病是这些患者颌骨骨髓炎的原因之一。
■评估COVID-19后患者因曲霉病引起的颌骨骨髓炎的发生率和模式，并讨论其治疗方案。
■数据是我们机构从2021年1月至2021年6月获得的。包括所有年龄组的因曲霉病引起的COVID-19后颌骨骨髓炎患者以及合并曲霉病和毛霉菌病感染的患者。排除了犀牛或脑真菌感染的患者。
■共有47名患者报告到我们中心。在人口统计学上，患者的平均年龄为49.11岁，其中72％为男性。所有47例患者（N=100％）均接受了类固醇治疗。其中21例（N=44.7％）患有糖尿病，14例（N=29.8％）患有其他合并症。在47名患者中，42例（N=89.7％）患者被诊断为曲霉病，其余5例（N=10.3％）患有毛霉菌病和曲霉病的混合真菌感染。在真菌培养中，黄曲霉是检测到的最常见的物种，其次是黑曲霉和烟曲霉。所有患者均口服伏立康唑和局部手术清创治疗。及时进行实验室测试，如及时安装KOH，半乳甘露聚糖试验,β-D-葡聚糖试验,组织标本的组织病理学可以帮助早期和明确的诊断。我们在这项研究中遇到的死亡率为零。
■早期明确诊断并立即开始抗真菌药物治疗和手术干预将大大降低发病率和死亡率。
■评估COVID-19后患者因曲霉病引起的颌骨骨髓炎的发生率和模式，并讨论其治疗方案。
■数据是我们机构从2021年1月至2021年6月获得的。包括所有年龄组的因曲霉病引起的COVID-19后颌骨骨髓炎患者以及合并曲霉病和毛霉菌病感染的患者。排除了犀牛或脑真菌感染的患者。
■共有47名患者报告到我们中心。在人口统计学上，患者的平均年龄为49.11岁，其中72％为男性。所有47例患者（N=100％）均接受了类固醇治疗。其中21例（N=44.7％）患有糖尿病，14例（N=29.8％）患有其他合并症。在47名患者中，42例（N=89.7％）患者被诊断为曲霉病，其余5例（N=10.3％）患有毛霉菌病和曲霉病的混合真菌感染。在真菌培养中，黄曲霉是检测到的最常见的物种，其次是黑曲霉和烟曲霉。所有患者均口服伏立康唑和局部手术清创治疗。及时进行实验室测试，如及时安装KOH，半乳甘露聚糖试验,β-D-葡聚糖试验,组织标本的组织病理学可以帮助早期和明确的诊断。我们在这项研究中遇到的死亡率为零。
■早期明确诊断并立即开始抗真菌药物治疗和手术干预将大大降低发病率和死亡率。
