PDF(Pubmed)
Abstract：
UNASSIGNED: Given the rising prevalence of high fasting plasma glucose (HFPG) over the past three decades, it is crucial to assess its global, national, and regional impact on chronic kidney disease (CKD). This study aims to investigate the burden of CKD attributed to HFPG and its distribution across various levels.
UNASSIGNED: The data for this research was sourced from the Global Burden of Diseases Study 2019. To estimate the burden of CKD attributed to HFPG, we utilized DisMod-MR 2.1, a Bayesian meta-regression tool. The burden was measured using age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life years (DALYs) rate. Correlation analysis was performed using the Spearman rank order correlation method. Temporal trends were analyzed by estimating the estimated annual percentage change (EAPC).
UNASSIGNED: Globally in 2019, there were a total of 487.97 thousand deaths and 13,093.42 thousand DALYs attributed to CKD attributed to HFPG, which represent a substantial increase of 153.8% and 120%, respectively, compared to 1990. Over the period from 1990 to 2019, the burden of CKD attributable to HFPG increased across all regions, with the highest increases observed in regions with high socio-demographic index (SDI) and middle SDI. Regions with lower SDI exhibited higher ASMR and age-standardized DALYs (ASDR) compared to developed nations at the regional level. Additionally, the EAPC values, which indicate the rate of increase, were significantly higher in these regions compared to developed nations. Notably, high-income North America, belonging to the high SDI regions, experienced the greatest increase in both ASMR and ASDR over the past three decades. Furthermore, throughout the years from 1990 to 2019, males bore a greater burden of CKD attributable to HFPG.
UNASSIGNED: With an increasing population and changing dietary patterns, the burden of CKD attributed to HFPG is expected to worsen. From 1990 to 2019, males and developing regions have experienced a more significant burden. Notably, the EAPC values for both ASMR and ASDR were higher in males and regions with lower SDI (excluding high-income North America). This emphasizes the pressing requirement for effective interventions to reduce the burden of CKD attributable to HFPG.
UNASSIGNED: The data for this research was sourced from the Global Burden of Diseases Study 2019. To estimate the burden of CKD attributed to HFPG, we utilized DisMod-MR 2.1, a Bayesian meta-regression tool. The burden was measured using age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life years (DALYs) rate. Correlation analysis was performed using the Spearman rank order correlation method. Temporal trends were analyzed by estimating the estimated annual percentage change (EAPC).
UNASSIGNED: Globally in 2019, there were a total of 487.97 thousand deaths and 13,093.42 thousand DALYs attributed to CKD attributed to HFPG, which represent a substantial increase of 153.8% and 120%, respectively, compared to 1990. Over the period from 1990 to 2019, the burden of CKD attributable to HFPG increased across all regions, with the highest increases observed in regions with high socio-demographic index (SDI) and middle SDI. Regions with lower SDI exhibited higher ASMR and age-standardized DALYs (ASDR) compared to developed nations at the regional level. Additionally, the EAPC values, which indicate the rate of increase, were significantly higher in these regions compared to developed nations. Notably, high-income North America, belonging to the high SDI regions, experienced the greatest increase in both ASMR and ASDR over the past three decades. Furthermore, throughout the years from 1990 to 2019, males bore a greater burden of CKD attributable to HFPG.
UNASSIGNED: With an increasing population and changing dietary patterns, the burden of CKD attributed to HFPG is expected to worsen. From 1990 to 2019, males and developing regions have experienced a more significant burden. Notably, the EAPC values for both ASMR and ASDR were higher in males and regions with lower SDI (excluding high-income North America). This emphasizes the pressing requirement for effective interventions to reduce the burden of CKD attributable to HFPG.
摘要：
■鉴于过去三十年来高空腹血糖（HFPG）的患病率上升，评估其全球至关重要，国家,以及对慢性肾脏病（CKD）的区域性影响。本研究旨在调查归因于HFPG的CKD负担及其在各个水平上的分布。
■这项研究的数据来自2019年全球疾病负担研究。为了估计归因于HFPG的CKD负担，我们使用DisMod-MR2.1，一种贝叶斯元回归工具。使用年龄标准化死亡率（ASMR）和年龄标准化残疾调整寿命年（DALYs）来衡量负担。采用Spearman秩相关方法进行相关分析。通过估计年度百分比变化(EAPC)来分析时间趋势。
■在2019年全球范围内，归因于HFPG的CKD的死亡总数为487.97万人，DALYs为13,093.42万人，分别大幅增长153.8%和120%，分别,与1990年相比。在1990年至2019年期间，HFPG引起的CKD负担在所有地区都有所增加，在具有高社会人口统计学指数（SDI）和中等SDI的地区观察到最高的增长。在区域一级，与发达国家相比，SDI较低的地区表现出更高的ASMR和年龄标准化的DALYs（ASDR）。此外,EAPC值，这表明了增长率，与发达国家相比，这些地区的比例要高得多。值得注意的是,高收入的北美，属于高SDI地区，在过去的三十年中，ASMR和ASDR的增幅最大。此外，从1990年到2019年，男性因HFPG而承担了更大的CKD负担。
■随着人口的增加和饮食模式的改变，归因于HFPG的CKD负担预计将恶化。从1990年到2019年，男性和发展中地区经历了更大的负担。值得注意的是,ASMR和ASDR的EAPC值在男性和SDI较低的地区(不包括北美高收入地区)均较高.这强调了迫切需要有效的干预措施，以减少归因于HFPG的CKD负担。
■这项研究的数据来自2019年全球疾病负担研究。为了估计归因于HFPG的CKD负担，我们使用DisMod-MR2.1，一种贝叶斯元回归工具。使用年龄标准化死亡率（ASMR）和年龄标准化残疾调整寿命年（DALYs）来衡量负担。采用Spearman秩相关方法进行相关分析。通过估计年度百分比变化(EAPC)来分析时间趋势。
■在2019年全球范围内，归因于HFPG的CKD的死亡总数为487.97万人，DALYs为13,093.42万人，分别大幅增长153.8%和120%，分别,与1990年相比。在1990年至2019年期间，HFPG引起的CKD负担在所有地区都有所增加，在具有高社会人口统计学指数（SDI）和中等SDI的地区观察到最高的增长。在区域一级，与发达国家相比，SDI较低的地区表现出更高的ASMR和年龄标准化的DALYs（ASDR）。此外,EAPC值，这表明了增长率，与发达国家相比，这些地区的比例要高得多。值得注意的是,高收入的北美，属于高SDI地区，在过去的三十年中，ASMR和ASDR的增幅最大。此外，从1990年到2019年，男性因HFPG而承担了更大的CKD负担。
■随着人口的增加和饮食模式的改变，归因于HFPG的CKD负担预计将恶化。从1990年到2019年，男性和发展中地区经历了更大的负担。值得注意的是,ASMR和ASDR的EAPC值在男性和SDI较低的地区(不包括北美高收入地区)均较高.这强调了迫切需要有效的干预措施，以减少归因于HFPG的CKD负担。
