UNASSIGNED: This multicenter ambispective cohort study, conducted from 4th August 2021 to 4th March 2023, examined strokes in women of reproductive years at the neurology outpatient/emergency department of five busiest/referred neuro-medical facilities in Karachi, Pakistan, where patients from across the nation are assessed. In all, 1210 patients were enrolled via consecutive or convenient sampling retrospectively from January 2017 to August 2021 and prospectively from August 2021 to March 2023. Pregnancy-related and non-pregnancy-related stroke occurrence and characteristics were compared using the chi-square/Fischer\'s exact test.
UNASSIGNED: 56% were non-pregnancy-related strokes and 44% were pregnancy-related strokes with non-pregnancy-related strokes approximately equal throughout the reproductive years (15-24 years = 34%, 25-34 years = 25%, 35-45 years = 41%) and pregnancy-related stroke between 15 and 35 years (82%). In the non-pregnancy-related stroke, arterial stroke dominated (96.4%); while in pregnancy-related stroke, arterial stroke accounted for 61.4% and venous stroke for 38.6% of cases. Middle cerebral artery was a typical stroke site (66%). Infarction was the most significant CT/MRI finding (PRS = 89%, NPRS = 66%), with pregnancy-related stroke hemorrhagic stroke occurring in only 11% of cases and non-pregnancy-related stroke comprising one-third (34%). The most prevalent etiologies were eclampsia in pregnancy-related stroke (32%), hypertension in non-pregnancy-related stroke (40%), and cardiac problems among both groups (25%:33%). Weakness and headache were the common clinical manifestations among both groups. In the pregnancy-related and non-pregnancy-related stroke groups, the initial presentation of stroke resulted in severe disability for 91% and 75%, respectively. With timely treatment, the outcome improved significantly. The mortality rate was 7% for the pregnancy-related stroke group and 4% for the non-pregnancy-related stroke group.
UNASSIGNED: Our findings show that stroke is prevalent among reproductive-year women, posing a significant mortality risk if not adequately recognized and treated. Awareness, research, and screening of stroke risk factors and their often-overlooked early presentation (i.e., headache and weakness) in reproductive years are essential to reducing stroke occurrence among reproductive-year women.
■这项多中心双向队列研究,从2021年8月4日至2023年3月4日进行,在卡拉奇五个最繁忙/转诊的神经医疗机构的神经科门诊/急诊科检查了育龄妇女的中风,巴基斯坦,对来自全国各地的患者进行评估。总之,从2017年1月至2021年8月,以及从2021年8月至2023年3月,通过连续或方便的采样回顾性纳入了1210例患者。使用卡方/Fischer精确检验比较妊娠相关和非妊娠相关中风的发生和特征。
■56%为非妊娠相关中风,44%为妊娠相关中风,非妊娠相关中风在整个生育年份大致相等(15-24岁=34%,25-34岁=25%,35-45岁=41%)和15至35岁之间的妊娠相关中风(82%)。在非妊娠相关的中风中,动脉卒中占主导地位(96.4%);而在妊娠相关卒中中,动脉卒中占61.4%,静脉卒中占38.6%。大脑中动脉是典型的卒中部位(66%)。梗死是最重要的CT/MRI发现(PRS=89%,NPRS=66%),妊娠相关中风出血性中风仅发生在11%的病例中,非妊娠相关中风占三分之一(34%)。最常见的病因是妊娠相关卒中的子痫(32%),非妊娠相关卒中的高血压(40%),和心脏问题在两组(25%:33%)。虚弱和头痛是两组患者常见的临床表现。在妊娠相关和非妊娠相关中风组中,中风的最初表现导致91%和75%的严重残疾,分别。及时治疗,结果明显改善。妊娠相关卒中组的死亡率为7%,非妊娠相关卒中组的死亡率为4%。
■我们的研究结果表明,中风在育龄妇女中很普遍,如果没有充分的认识和治疗,会带来巨大的死亡风险。意识,研究,和筛查中风危险因素及其经常被忽视的早期表现(即,生殖年份的头痛和虚弱)对于减少生殖年份妇女的中风发生率至关重要。