PDF(Pubmed)
Abstract：
UNASSIGNED: Recently, observational studies have reported that gastroesophageal reflux disease (GERD) is commonly associated with irritable bowel syndrome (IBS), but the causal relationship is unclear.
UNASSIGNED: We conducted a two-sample Mendelian randomization study using summary data from genome-wide association studies (GWASs) to explore a causal relationship between GERD (N cases = 129,080) and IBS (N cases = 4,605) of European ancestry. Furthermore, the inverse-variance weighted (IVW) method and a series of sensitivity analyses were used to assess the accuracy and confidence of our results.
UNASSIGNED: We found a significant association of GERD with IBS (NSNP = 74; OR: 1.375; 95% CI: 1.164-1.624; p < 0.001). Reverse MR analysis showed no evidence of a causal association for IBS with GERD (NSNP = 6; OR: 0.996; 95% CI: 0.960-1.034; p = 0.845).
UNASSIGNED: This study provides evidence that the presence of GERD increases the risk of developing IBS, and it is observed from the reverse MR results that IBS did not increase the risk of GERD.
UNASSIGNED: We conducted a two-sample Mendelian randomization study using summary data from genome-wide association studies (GWASs) to explore a causal relationship between GERD (N cases = 129,080) and IBS (N cases = 4,605) of European ancestry. Furthermore, the inverse-variance weighted (IVW) method and a series of sensitivity analyses were used to assess the accuracy and confidence of our results.
UNASSIGNED: We found a significant association of GERD with IBS (NSNP = 74; OR: 1.375; 95% CI: 1.164-1.624; p < 0.001). Reverse MR analysis showed no evidence of a causal association for IBS with GERD (NSNP = 6; OR: 0.996; 95% CI: 0.960-1.034; p = 0.845).
UNASSIGNED: This study provides evidence that the presence of GERD increases the risk of developing IBS, and it is observed from the reverse MR results that IBS did not increase the risk of GERD.
摘要：
■最近，观察性研究报道胃食管反流病(GERD)通常与肠易激综合征(IBS)相关,但因果关系尚不清楚。
■我们使用来自全基因组关联研究（GWAS）的汇总数据进行了两个样本的孟德尔随机化研究，以探索GERD（N例=129,080）和欧洲血统的IBS（N例=4,605）之间的因果关系。此外，我们使用了逆方差加权(IVW)方法和一系列敏感性分析来评估我们结果的准确性和置信度.
■我们发现GERD与IBS显著相关(NSNP=74;OR:1.375;95%CI:1.164-1.624;p<0.001)。反向MR分析没有证据表明IBS与GERD有因果关系(NSNP=6;OR:0.996;95%CI:0.960-1.034;p=0.845)。
■这项研究提供了证据，证明GERD的存在会增加IBS的风险，从反向MR结果观察到IBS没有增加GERD的风险.
■我们使用来自全基因组关联研究（GWAS）的汇总数据进行了两个样本的孟德尔随机化研究，以探索GERD（N例=129,080）和欧洲血统的IBS（N例=4,605）之间的因果关系。此外，我们使用了逆方差加权(IVW)方法和一系列敏感性分析来评估我们结果的准确性和置信度.
■我们发现GERD与IBS显著相关(NSNP=74;OR:1.375;95%CI:1.164-1.624;p<0.001)。反向MR分析没有证据表明IBS与GERD有因果关系(NSNP=6;OR:0.996;95%CI:0.960-1.034;p=0.845)。
■这项研究提供了证据，证明GERD的存在会增加IBS的风险，从反向MR结果观察到IBS没有增加GERD的风险.
