PDF(Pubmed)
Abstract：
The endometrium undergoes a series of precise monthly changes under the regulation of dynamic levels of ovarian hormones that are characterized by repeated shedding and subsequent regeneration without scarring. This provides the potential for wound healing during endometrial injuries. Bioengineering materials highlight the faithful replication of constitutive cells and the extracellular matrix that simulates the physical and biomechanical properties of the endometrium to a larger extent. Significant progress has been made in this field, and functional endometrial tissue bioengineering allows an in-depth investigation of regulatory factors for endometrial and myometrial defects in vitro and provides highly therapeutic methods to alleviate obstetric and gynecological complications. However, much remains to be learned about the latest progress in the application of bioengineering technologies to the human endometrium. Here, we summarize the existing developments in biomaterials and bioengineering models for endometrial regeneration and improving the female reproductive potential.
摘要：
子宫内膜在卵巢激素动态水平的调节下经历一系列精确的每月变化，其特征是反复脱落和随后的再生而没有疤痕。这提供了子宫内膜损伤期间伤口愈合的潜力。生物工程材料突出了组成型细胞和细胞外基质的忠实复制，在更大程度上模拟了子宫内膜的物理和生物力学特性。在这一领域取得了重大进展,和功能性子宫内膜组织生物工程允许在体外深入研究子宫内膜和子宫肌层缺损的调节因素，并提供了缓解产科和妇科并发症的高度治疗方法。然而,关于将生物工程技术应用于人类子宫内膜的最新进展，还有很多尚待了解。这里,我们总结了子宫内膜再生和提高女性生殖潜能的生物材料和生物工程模型的现有发展。
