METHODS: Data from multiple centers were used to identify de novo glomerulonephritis (GN) cases with suspected onset following COVID-19 infection or vaccination. Retrospective surveys were used to determine the COVID-19-related histories of patients who were initially not implicated. Bayesian structural time series and autoregressive integrated moving average models were used to determine causality.
RESULTS: Glomerular diseases occurred shortly after the infection or vaccination. The most prevalent postinfection GN was podocytopathy (42.9%), comprising primary focal segmental glomerulosclerosis and minimal change disease, whereas postvaccination GN mainly included immunoglobulin A nephropathy (IgAN; 57.9%) and Henoch-Schönlein purpura nephritis (HSP; 15.8%). No patient progressed to end-stage kidney disease. Among the patients who were initially not implicated, nine patients with IgAN/HSP were recently vaccinated against COVID-19. The proportion of glomerular diseases changed during the pandemic in South Korea, with an increase in acute interstitial nephritis and a decrease in pauci-immune crescentic GN.
CONCLUSIONS: This study showed the characteristics of GNs following COVID-19 infection or vaccination in South Korea. Understanding these associations is crucial for developing effective patient management and vaccination strategies. Further investigation is required to fully comprehend COVID-19\'s impact on GN.
方法:使用来自多个中心的数据来鉴定怀疑在COVID-19感染或接种疫苗后发病的新生肾小球肾炎(GN)病例。回顾性调查用于确定最初没有牵连的患者的COVID-19相关病史。使用贝叶斯结构时间序列和自回归积分移动平均模型来确定因果关系。
结果:肾小球疾病在感染或接种疫苗后不久发生。感染后最常见的GN是足细胞病(42.9%),包括原发性局灶性节段肾小球硬化和微小病变,而接种后GN主要包括免疫球蛋白A肾病(IgAN;57.9%)和过敏性紫癜性肾炎(HSP;15.8%)。没有患者进展为终末期肾病。在最初没有牵连的患者中,9例IgAN/HSP患者最近接种了COVID-19疫苗。在韩国大流行期间肾小球疾病的比例发生了变化,随着急性间质性肾炎的增加和少汁免疫新月体GN的减少。
结论:这项研究显示了韩国COVID-19感染或接种疫苗后GNs的特征。了解这些关联对于制定有效的患者管理和疫苗接种策略至关重要。需要进一步调查才能充分了解COVID-19对GN的影响。