Abstract：
Obesity is associated with dysfunctions in hypothalamic neurons that regulate metabolism, including agouti-related protein (AgRP)-expressing neurons. In a recent article, Zhang et al. demonstrated that either diet- or genetically induced obesity promoted iron accumulation specifically in AgRP neurons. Preventing iron overload in AgRP neurons mitigated diet-induced obesity and related comorbidities in male mice.
摘要：
肥胖与调节代谢的下丘脑神经元功能障碍有关，包括agouti相关蛋白(AgRP)表达神经元。在最近的一篇文章中，张等人。证明了饮食或遗传诱导的肥胖促进了AgRP神经元中特定的铁积累。在雄性小鼠中预防AgRP神经元中的铁过载减轻了饮食诱导的肥胖和相关的合并症。
