Abstract：
Polypharmacy exacerbates lower urinary tract symptoms (LUTS). Japan exhibits a higher prevalence of concomitant medication use in drug therapy than other countries. Previous age- and sex-specific reports exist; however, none include patients of all ages. Therefore, this retrospective study determined the impact of polypharmacy and its associated risk factors on LUTS exacerbation in outpatients with urological conditions. We included patients receiving medication who visited the Department of Urology at the Gifu Municipal Hospital (Gifu, Japan) between January, 2018 and December, 2018. The association between LUTS and polypharmacy and the risk factors for LUTS exacerbation were investigated. Patients were categorized into two groups according to their polypharmacy status. We performed propensity score matching and compared the International Prostate Symptom Score (IPSS) between the groups using the unpaired t-test. Multiple logistic regression analysis was performed to examine the risk factors, including \"polypharmacy\" and \"taking multiple anticholinergic medications\" for LUTS exacerbation. When comparing the IPSS between the groups, the polypharmacy group was found to have significantly higher scores than the non-polypharmacy group in six items, including \"total score\" and \"storage score.\" Multiple logistic regression analysis results showed high significance in three items, including \"polypharmacy\" (odds ratio (OR) = 1.67, 95% confidence interval (CI): 1.03-2.71) and \"taking multiple anticholinergic medications\" (OR = 8.68, 95% CI: 1.05-71.7). In conclusion, this study revealed that \"polypharmacy\" and \"taking multiple anticholinergic medications\" were risk factors for LUTS. Particularly, \"polypharmacy\" is associated with storage symptom exacerbation. Therefore, eliminating \"polypharmacy\" and \"taking multiple anticholinergic medications\" is expected to improve LUTS.
摘要：
多重用药会加剧下尿路症状（LUTS）。与其他国家相比，日本在药物治疗中同时使用药物的患病率更高。以前存在特定年龄和性别的报告；然而，没有一个包括所有年龄段的患者。因此,这项回顾性研究确定了多重用药及其相关危险因素对泌尿系统疾病门诊患者LUTS加重的影响.我们包括在Gifu市医院泌尿外科就诊的接受药物治疗的患者（Gifu，Japan)betweenJanuary,2018年12月,2018.研究了LUTS与多重用药之间的关系以及LUTS加重的危险因素。根据患者的多重用药状态将患者分为两组。我们进行了倾向评分匹配，并使用非配对t检验比较了两组之间的国际前列腺症状评分（IPSS）。进行多元logistic回归分析以检查危险因素，包括“多重用药”和“服用多种抗胆碱能药物治疗”。比较各组之间的IPSS时，发现多重用药组在六个项目上的得分明显高于非多重用药组，包括“总分”和“存储得分”。“多元logistic回归分析结果显示三个项目有很高的显著性，包括“多重用药”(比值比(OR)=1.67,95%置信区间(CI):1.03-2.71)和“服用多种抗胆碱能药物”(OR=8.68,95%CI:1.05-71.7)。总之,这项研究表明，“多重用药”和“服用多种抗胆碱能药物”是LUTS的危险因素。特别是,“多重用药”与储存症状恶化有关。因此,消除“多重用药”和“服用多种抗胆碱能药物”有望改善LUTS。
