Mesh : Antifungal Agents / pharmacology chemical synthesis chemistry Spiro Compounds / pharmacology chemistry chemical synthesis Water / chemistry Indoles / chemistry pharmacology chemical synthesis Microbial Sensitivity Tests Oxindoles / pharmacology chemical synthesis chemistry Molecular Structure Structure-Activity Relationship Fusarium / drug effects Benzopyrans Nitriles

来  源:   DOI:10.1039/d4ob00256c

Abstract:
A water mediated three-component reaction of isatin, 4-aminocoumarin, and 1,3-cyclodicarbonyl compounds is reported for the synthesis of spiro[chromeno[4,3-b]cyclopenta[e]pyridine-7,3\'-indoline]trione and the spiro[chromeno[4,3-b]quinoline 7,3\'-indoline]trione. Up to 27 different spirooxindole derivatives were synthesized by this method. The bioactivity of these spirooxindole derivatives was evaluated and they were found to show antifungal activity against Cercospora arachidicola, Physalospora piricola, Rhizoctonia cerealis, and Fusarium moniliforme.
摘要:
一种水介导的三组分反应,4-氨基香豆素,据报道,1,3-环二羰基化合物用于合成螺[苯并[4,3-b]环戊二烯[e]吡啶-7,3'-二氢吲哚]三酮和螺[苯并[4,3-b]喹啉7,3'-二氢吲哚]三酮。通过该方法合成了多达27种不同的螺羟吲哚衍生物。对这些螺羟吲哚衍生物的生物活性进行了评估,发现它们对花生尾孢菌具有抗真菌活性,Physalosporapiricola,谷物根瘤菌,和镰刀菌。
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