Abstract：
Myokines, released from the muscle, enable communication between the working muscles and other tissues. Their release during physical exercise is assumed to depend on immune-hormonal-metabolic interactions concerning mode (endurance or resistance exercise), duration, and intensity. This meta-analysis aims to examine the acute changes of circulating myokines inducing immunoregulatory effects caused by a bout of resistance exercise and to consider potential moderators of the results. Based on this selection strategy, a systematic literature search was conducted for resistance exercise intervention studies measuring interleukin (IL-) 6, IL-10, IL-1ra, tumor necrosis factor (TNF-) α, IL-15, IL-7, transforming growth factor (TGF-) β1, and fractalkines (FKN) before and immediately after resistance exercise in healthy individuals. Random-effects meta-analysis was performed for each myokine. We identified a moderate positive effect of resistance exercise for IL-6 and IL-1ra. Regarding IL-15 and TNF-α, small to moderate effects were found. For IL-10, no significant effect was observed. Due to no data, meta-analyses for IL-7, TGF-β1, and FKN could not be performed. No moderators (training status, type of exercise, risk of bias, age, sex, time of day, exercise volume, exercise intensity, exercise dose) of the results were detected for all tested myokines. Taken together, this systematic review and meta-analysis showed immediate positive effects of an acute resistance exercise session on IL-6, IL-1ra, TNF-α, and IL-15 levels.
摘要：
Myokines,从肌肉中释放出来，使工作肌肉和其他组织之间的交流。它们在体育锻炼过程中的释放被认为取决于免疫-激素-代谢相互作用，涉及模式（耐力或抵抗运动），持续时间,和强度。这项荟萃分析旨在研究由一次抵抗运动引起的循环肌细胞诱导免疫调节作用的急性变化，并考虑结果的潜在调节剂。基于这种选择策略，对测量白细胞介素（IL-）6，IL-10，IL-1ra，肿瘤坏死因子(TNF-α),在健康人进行抵抗运动之前和之后，IL-15，IL-7，转化生长因子（TGF-）β1和fractalkines（FKN）。对每种肌肉因子进行随机效应荟萃分析。我们确定了抗阻运动对IL-6和IL-1ra的中度积极作用。关于IL-15和TNF-α，发现了小到中等的影响。对于IL-10,没有观察到显著的效果。由于没有数据,无法进行IL-7，TGF-β1和FKN的荟萃分析。没有主持人(培训状态，运动类型,偏见的风险，年龄,性别,一天的时间,运动量,运动强度,运动剂量）对所有测试的肌细胞因子进行了检测。一起来看,这项系统评价和荟萃分析显示，急性抵抗运动对IL-6，IL-1ra，TNF-α,和IL-15水平。
