METHODS: A literature search of PubMed, Scopus and Web of Science was conducted on 17 January 2023, using the key terms \"T1DM,\" \"Eating Disorders\" and \"Bulimia.\" Only observational controlled studies were included. The Revman software (version 5.4) was used for the analysis.
RESULTS: T1DM was associated with increased risk of ED compared with nondiabetic individuals (RR = 2.47, 95% CI = 1.84-3.32, p-value < 0.00001), especially bulimia nervosa (RR = 2.80, 95% CI = 1.18-6.65, p-value = 0.02) and binge eating (RR = 1.53, 95% CI = 1.18-1.98, p-value = 0.001). Our analysis has shown that increased risk of ED among T1DM persisted regardless of the questionnaire used to diagnose ED; DM-validated questionnaires (RR = 2.80, 95% CI = 1.91-4.12, p-value < 0.00001) and generic questionnaires (RR = 2.03, 95% CI = 1.27-3.23, p-value = 0.003). Prevalence of insulin omission/misuse was 10.3%; diabetic females demonstrated a significantly higher risk of insulin omission and insulin misuse than diabetic males.
CONCLUSIONS: Our study establishes a significant and clear connection between EDs and T1DM, particularly bulimia and binge eating, with T1DM. Moreover, female diabetics are at higher risk of insulin misuse/omission. Early proactive screening is essential and tailored; comprehensive interventions combining diabetes and ED components are recommended for this population, with referral to a specialised psychiatrist.
方法:PubMed的文献检索,Scopus和WebofScience于2023年1月17日进行,使用关键术语“T1DM,\"\"进食障碍\"和\"贪食症。“仅包括观察性对照研究。使用Revman软件(版本5.4)进行分析。
结果:与非糖尿病个体相比,T1DM与ED风险增加相关(RR=2.47,95%CI=1.84-3.32,p值<0.00001),尤其是神经性暴食症(RR=2.80,95%CI=1.18-6.65,p值=0.02)和暴饮暴食(RR=1.53,95%CI=1.18-1.98,p值=0.001)。我们的分析表明,无论用于诊断ED的问卷如何,T1DM的ED风险增加仍然存在;DM验证问卷(RR=2.80,95%CI=1.91-4.12,p值<0.00001)和通用问卷(RR=2.03,95%CI=1.27-3.23,p值=0.003)。胰岛素遗漏/误用的患病率为10.3%;糖尿病女性的胰岛素遗漏和胰岛素误用风险明显高于糖尿病男性。
结论:我们的研究在ED和T1DM之间建立了重要而明确的联系,尤其是暴食症和暴饮暴食,T1DM此外,女性糖尿病患者胰岛素误用/遗漏的风险较高.早期主动筛查是必要和量身定制的;建议对该人群进行综合干预,结合糖尿病和ED成分。转诊给专门的精神病医生.