PDF(Pubmed)
Abstract：
OBJECTIVE: This study aimed to assess the efficacy and safety of facial artery musculomucosal (FAMM) flap for small-medium tongue or floor of mouth defects caused by surgical resection of early-medium stage tongue or floor of mouth cancer.
METHODS: A retrospective cohort study was conducted and included patients with early-medium stage tongue or floor of mouth cancer and reconstructed by FAMM flap or traditional free or axial flaps. Demographic data and surgery-related data were collected. Patients were followed up for 6 months and evaluated with satisfaction, maximal mouth opening, satisfactory contour and speech, and oral intake function at months 3 and 6.
RESULTS: Forty-five patients were included, with 15 in the FAMM group and 30 in the flap group. All patients finished 3 months follow-up, and 1 in each group was lost to follow-up at month 6. All followed-up patients had no recurrence or metastasis. The FAMM group had a significantly shorter surgical time than the flap group (P<0.05). The flap group had significantly more donor sites that were uncomfortable compared with the FAMM group (P<0.05). There was no statistical significance on satisfaction, but the FAMM group had better outcomes on contour, speech, and oral intake function at month 6 than the flap group (P<0.05). The FAMM group had smaller maximal mouth opening than the flap group (P<0.05) at month 3 but equivalent maximal mouth opening at month 6 (P>0.05).
CONCLUSIONS: FAMM flap has some advantages for small-medium tongue or floor of mouth defects caused by surgical resection of early-medium stage tongue or floor of mouth cancer, and it could be an ideal choice for clinical application.
目的: 探究以面动脉为蒂的黏膜肌（FAMM）瓣在修复临床早-中期舌癌及口底癌缺损中的临床效果及安全性。方法: 通过回顾性队列研究的方式纳入使用FAMM瓣（FAMM组）或者皮瓣（皮瓣组）修复早-中期舌癌、口底癌切除后中小型舌、口底缺损的患者，收集患者一般资料及相关手术资料，术后3个月和6个月评估患者满意度、张口度、外形满意度、语音满意度以及进食功能情况。结果: 本研究共纳入患者45名，其中FAMM组15名，皮瓣组30名。所有患者均完成了术后3个月随访，2组各1名患者在术后6个月失访，随访到的患者没有复发及转移征象。FAMM组手术时间短于皮瓣组（P<0.05）。皮瓣组患者术后供瓣区不适多于FAMM组（P<0.05）。2组患者术后总体满意度差异无统计学意义（P>0.05），但FAMM组术后6个月外形满意度、语音满意度和进食功能优于皮瓣组（P<0.05）；术后3个月张口度FAMM组小于皮瓣组（P<0.05），但术后6个月2组差异无统计学意义（P>0.05）。结论: FAMM瓣修复早-中期舌、口底癌切除后中小型的舌、口底缺损具有一定的优势，可以在临床中考虑使用。.
METHODS: A retrospective cohort study was conducted and included patients with early-medium stage tongue or floor of mouth cancer and reconstructed by FAMM flap or traditional free or axial flaps. Demographic data and surgery-related data were collected. Patients were followed up for 6 months and evaluated with satisfaction, maximal mouth opening, satisfactory contour and speech, and oral intake function at months 3 and 6.
RESULTS: Forty-five patients were included, with 15 in the FAMM group and 30 in the flap group. All patients finished 3 months follow-up, and 1 in each group was lost to follow-up at month 6. All followed-up patients had no recurrence or metastasis. The FAMM group had a significantly shorter surgical time than the flap group (P<0.05). The flap group had significantly more donor sites that were uncomfortable compared with the FAMM group (P<0.05). There was no statistical significance on satisfaction, but the FAMM group had better outcomes on contour, speech, and oral intake function at month 6 than the flap group (P<0.05). The FAMM group had smaller maximal mouth opening than the flap group (P<0.05) at month 3 but equivalent maximal mouth opening at month 6 (P>0.05).
CONCLUSIONS: FAMM flap has some advantages for small-medium tongue or floor of mouth defects caused by surgical resection of early-medium stage tongue or floor of mouth cancer, and it could be an ideal choice for clinical application.
目的: 探究以面动脉为蒂的黏膜肌（FAMM）瓣在修复临床早-中期舌癌及口底癌缺损中的临床效果及安全性。方法: 通过回顾性队列研究的方式纳入使用FAMM瓣（FAMM组）或者皮瓣（皮瓣组）修复早-中期舌癌、口底癌切除后中小型舌、口底缺损的患者，收集患者一般资料及相关手术资料，术后3个月和6个月评估患者满意度、张口度、外形满意度、语音满意度以及进食功能情况。结果: 本研究共纳入患者45名，其中FAMM组15名，皮瓣组30名。所有患者均完成了术后3个月随访，2组各1名患者在术后6个月失访，随访到的患者没有复发及转移征象。FAMM组手术时间短于皮瓣组（P<0.05）。皮瓣组患者术后供瓣区不适多于FAMM组（P<0.05）。2组患者术后总体满意度差异无统计学意义（P>0.05），但FAMM组术后6个月外形满意度、语音满意度和进食功能优于皮瓣组（P<0.05）；术后3个月张口度FAMM组小于皮瓣组（P<0.05），但术后6个月2组差异无统计学意义（P>0.05）。结论: FAMM瓣修复早-中期舌、口底癌切除后中小型的舌、口底缺损具有一定的优势，可以在临床中考虑使用。.
摘要：
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