PDF(Pubmed)
Abstract：
UNASSIGNED: Talaromyces marneffei (TM) is the third most prevalent opportunistic infection in HIV-positive patients after tuberculosis and cryptococcosis. However, such infection of non-HIV individuals has rarely been reported.
UNASSIGNED: We describe a very rare case of a 52-year-old male who presented with a single space-occupying lesion on the right lung and was eventually diagnosed with pulmonary TM infection. The patient was HIV-negative and had liver cirrhosis with portal vein thrombosis. Lung tissue next-generation sequencing (NGS) revealed TM infection. We successfully treated the patient with voriconazole for 8 weeks and observed lesion absorption via subsequent CT. The patient consumed wild bamboo rats two months before admission. Mutations related to congenital immune deficiency were not detected by whole-exome sequencing.
UNASSIGNED: Early and timely diagnosis is critical for improving patient prognosis. NGS plays a vital role in the diagnosis of pulmonary TM infection in patients. To our knowledge, this is the first published case of pulmonary TM infection in an HIV-negative patient with liver cirrhosis.
UNASSIGNED: We describe a very rare case of a 52-year-old male who presented with a single space-occupying lesion on the right lung and was eventually diagnosed with pulmonary TM infection. The patient was HIV-negative and had liver cirrhosis with portal vein thrombosis. Lung tissue next-generation sequencing (NGS) revealed TM infection. We successfully treated the patient with voriconazole for 8 weeks and observed lesion absorption via subsequent CT. The patient consumed wild bamboo rats two months before admission. Mutations related to congenital immune deficiency were not detected by whole-exome sequencing.
UNASSIGNED: Early and timely diagnosis is critical for improving patient prognosis. NGS plays a vital role in the diagnosis of pulmonary TM infection in patients. To our knowledge, this is the first published case of pulmonary TM infection in an HIV-negative patient with liver cirrhosis.
摘要：
■马尔尼菲Talaromyces（TM）是仅次于结核病和隐球菌病的HIV阳性患者中第三大流行的机会性感染。然而,这种非HIV个体的感染很少被报道。
■我们描述了一个非常罕见的病例，一名52岁的男性，他在右肺上出现了单个占位病变，最终被诊断为肺部TM感染。该患者为HIV阴性，患有肝硬化并伴有门静脉血栓形成。肺组织下一代测序(NGS)显示TM感染。我们成功地用伏立康唑治疗了患者8周，并通过随后的CT观察到病变吸收。患者在入院前两个月食用了野生竹鼠。通过全外显子组测序未检测到与先天性免疫缺陷相关的突变。
■早期及时诊断对于改善患者预后至关重要。NGS在肺部TM感染患者的诊断中起着至关重要的作用。据我们所知,这是首例已发表的HIV阴性肝硬化患者肺部TM感染病例.
■我们描述了一个非常罕见的病例，一名52岁的男性，他在右肺上出现了单个占位病变，最终被诊断为肺部TM感染。该患者为HIV阴性，患有肝硬化并伴有门静脉血栓形成。肺组织下一代测序(NGS)显示TM感染。我们成功地用伏立康唑治疗了患者8周，并通过随后的CT观察到病变吸收。患者在入院前两个月食用了野生竹鼠。通过全外显子组测序未检测到与先天性免疫缺陷相关的突变。
■早期及时诊断对于改善患者预后至关重要。NGS在肺部TM感染患者的诊断中起着至关重要的作用。据我们所知,这是首例已发表的HIV阴性肝硬化患者肺部TM感染病例.
